Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
1R01AR044741-01A2
Application #
2756633
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Program Officer
Sharrock, William J
Project Start
1999-02-01
Project End
2003-01-31
Budget Start
1999-02-01
Budget End
2000-01-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Forsyth Institute
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02142
Chen, Wei; Zhu, Guochun; Tang, Jun et al. (2018) C/ebp? controls osteoclast terminal differentiation, activation, function, and postnatal bone homeostasis through direct regulation of Nfatc1. J Pathol 244:271-282
Chen, Wei; Zhu, Guochun; Jules, Joel et al. (2018) Monocyte-Specific Knockout of C/ebp? Results in Osteopetrosis Phenotype, Blocks Bone Loss in Ovariectomized Mice, and Reveals an Important Function of C/ebp? in Osteoclast Differentiation and Function. J Bone Miner Res 33:691-703
Huang, Hong; Wang, Jue; Zhang, Yan et al. (2018) Bone resorption deficiency affects tooth root development in RANKL mutant mice due to attenuated IGF-1 signaling in radicular odontoblasts. Bone 114:161-171
Jules, Joel; Li, Yi-Ping; Chen, Wei (2018) C/EBP? and PU.1 exhibit different responses to RANK signaling for osteoclastogenesis. Bone 107:104-114
Jules, Joel; Chen, Wei; Feng, Xu et al. (2018) C/EBP? transcription factor is regulated by the RANK cytoplasmic 535IVVY538 motif and stimulates osteoclastogenesis more strongly than c-Fos. J Biol Chem 293:1480-1492
Pan, Jie; Wang, Jue; Hao, Liang et al. (2017) The Triple Functions of D2 Silencing in Treatment of Periapical Disease. J Endod 43:272-278
McConnell, Matthew; Feng, Shengmei; Chen, Wei et al. (2017) Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity. Oncotarget 8:47675-47690
Wu, Mengrui; Wang, Yiping; Shao, Jian-Zhong et al. (2017) Cbf? governs osteoblast-adipocyte lineage commitment through enhancing ?-catenin signaling and suppressing adipogenesis gene expression. Proc Natl Acad Sci U S A 114:10119-10124
Wu, Mengrui; Chen, Wei; Lu, Yun et al. (2017) G?13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3?-NFATc1 signalling pathway. Nat Commun 8:13700
Jules, Joel; Chen, Wei; Feng, Xu et al. (2016) CCAAT/Enhancer-binding Protein ? (C/EBP?) Is Important for Osteoclast Differentiation and Activity. J Biol Chem 291:16390-403

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