The long term objective of this work is to develop a new method of intra articular imaging to overcome current limitations in reheumatologic diagnostic imaging. Recent reports suggesting that the progression of articular cartilage damage in osteoar-thritis may be modified have heightened the need for better methods to image early changes in cartilage and monitor the progression of these changes. A variety of imaging modalities have been applied to the assessment of early osteoarthritic abnormalities with limited results. The hypothesis is that optical coherence tomography (OCT), a new method of fiber optic based micron scale imaging, can be developed as a method of high resolution, minimally invasive, intra articular imaging to address current limitations in joint diagnostics. OCT is analogous to ultrasound B mode imaging using infrared light rather than acoustical waves. OCT is attractive for intra articular diagnostic imaging because of its high resolution (4-20 um), broad dynamic range (110 dB), small compact design and ability to perform imaging through small optical fibers. The applicants proposed to test the hypothesis principally through background feasibility experiments designed to assess the ultimate utility of the approach. These background experiments focus on identifying advantages and limitations of OCT for intra articular imaging and maximizing performance.
The specific aims are to: 1. To perform imaging on a wide range of articular cartilage to identify limitations and advantages associated with OCT imaging. 2. To use the quantitized nature of light-molecular interaction to spectroscopically explore the biochemical changes of osteoarthritic articular cartilage. 3. To demonstrate the ability of OCT to perform in vivo imaging in a rabbit knee joint.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR044812-04
Application #
6341783
Study Section
Special Emphasis Panel (ZRG7-DMG (01))
Program Officer
Tyree, Bernadette
Project Start
1998-01-12
Project End
2003-12-31
Budget Start
2001-01-01
Budget End
2001-12-31
Support Year
4
Fiscal Year
2001
Total Cost
$263,431
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Brezinski, M E (2018) A Quantum Field Approach for Advancing Optical Coherence Tomography Part I: First Order Correlations, Single Photon Interference, and Quantum Noise. J Lasers Opt Photonics 5:
Brezinski, Mark E (2014) Practical Challenges of Current Video Rate OCT Elastography: Accounting for Dynamic and Static Tissue Properties. J Lasers Opt Photonics 1:
Brezinski, Mark E; Harjai, Kishore J (2014) Current OCT Approaches Do Not Reliably Identify TCFAs. J Clin Exp Cardiolog 5:
Brezinski, Mark E; Rupnick, Maria (2014) Can We Advance Macroscopic Quantum Systems Outside the Framework of Complex Decoherence Theory? J Comput Sci Syst Biol 7:119-136
Brezinski, Mark E; Harjai, Kishore J (2014) Longitudinal necrotic shafts near TCFAs--a potential novel mechanism for plaque rupture to trigger ACS? Int J Cardiol 177:738-41
Rashidifard, Christopher; Vercollone, Christopher; Martin, Scott et al. (2013) The application of optical coherence tomography in musculoskeletal disease. Arthritis 2013:563268
Rashidifard, Christopher; Martin, Scott; Kumar, Namita et al. (2012) Single-detector polarization-sensitive optical coherence tomography for assessment of rotator cuff tendon integrity. Am J Orthop (Belle Mead NJ) 41:351-7
Liu, Bin; Vercollone, Christopher; Brezinski, Mark E (2012) Towards improved collagen assessment: polarization-sensitive optical coherence tomography with tailored reference arm polarization. Int J Biomed Imaging 2012:892680
Brezinski, Mark E (2012) The Advantages of Not Entangling Macroscopic Diamonds at Room Temperature. J At Mol Opt Phys 2012:
Brezinski, Mark E (2011) Current capabilities and challenges for optical coherence tomography as a high-impact cardiovascular imaging modality. Circulation 123:2913-5

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