Injury to the anterior cruciate ligament (ACL) results in a threat to an active lifestyle and exposes the patient to risk of early osteoarthritis. ACL reconstruction is typically chosen by individuals to allow a return to their previous work and sports activities. The results of primary ACL reconstruction have in general been good at restoring functional stability, but patients'long-term outcome remains unknown. The Multicenter Orthopaedic Outcomes Network (MOON) is an established consortium designed to enroll and longitudinally follow a population cohort of ACL reconstructed patients to determine the modifiable predictors (or risk factors) of long-term outcomes of ACL reconstruction in order to establish patient-specific predictive models of clinically important outcomes. The objective of this prospective multicenter cohort of ACL reconstructions is to identify both the long-term prognosis and the potentially modifiable predictors of symptoms of osteoarthritis (OA), sports function, activity and general health through validated patient- reported outcomes, and incidence of ACL reconstruction graft and/or contralateral ACL failures. Our initial grant (R01 AR053684) allowed us to enroll over 2,300 patients and obtain both 2 and 6 year follow-up on this cohort. At both time points, we have been able to obtain a minimum of 85% follow-up using validated patient-reported outcome questionnaires and 93% via phone follow-up. Two of the original three Aims from the parent grant will be advanced in this competitive revision, 1) validated patient-reported outcomes of sports function, activity level, general health, and symptomatic OA, and 2) ACL graft or contralateral ACL failures. The objective of this revision is to complete 6 year follow-up on an additional unfunded MOON cohort of 1251 ACL reconstructed patients (with an already completed 86% 2 year follow-up rate) in the last 1.5 years of the parent grant (4/2014 - 8/2015). This would increase our existing sample size by ~ 50%, and would enable us to build the most comprehensive """"""""personalized"""""""" models to address detailed contributions of meniscus and articular cartilage injury and treatment (and their interactions) to several patient reported outcomes and OA symptoms. Furthermore, we would be the first to perform complex multivariable predictive modeling of ACL graft and contralateral ACL failure. The additional variables incorporated into longer 6 year time interval is particularly important for establishing the longer-term outcomes and symptoms of OA and incidence of both ipsilateral and contralateral ACL tears.

Public Health Relevance

This multicenter, multi-surgeon prospective study will allow determination of the clinical predictors of inferior outcomes following ACL reconstruction. Once the predictors for good and poor outcomes are identified, surgeons and patients can be educated to the potential modifiable variables that improve patient's outcomes.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Research Project (R01)
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Musculoskeletal Rehabilitation Sciences Study Section (MRS)
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Panagis, James S
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Vanderbilt University Medical Center
Schools of Medicine
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MOON Knee Group; Spindler, Kurt P; Huston, Laura J et al. (2018) Ten-Year Outcomes and Risk Factors After Anterior Cruciate Ligament Reconstruction: A MOON Longitudinal Prospective Cohort Study. Am J Sports Med 46:815-825
Houck, Darby A; Kraeutler, Matthew J; Vidal, Armando F et al. (2018) Variance in Anterior Cruciate Ligament Reconstruction Graft Selection based on Patient Demographics and Location within the Multicenter Orthopaedic Outcomes Network Cohort. J Knee Surg 31:472-478
Jones, Morgan H; MOON Knee Group; Spindler, Kurt P et al. (2018) Differences in the Lateral Compartment Joint Space Width After Anterior Cruciate Ligament Reconstruction: Data From the MOON Onsite Cohort. Am J Sports Med 46:876-882
Vega, José F; Spindler, Kurt P (2018) To MOON and Back: Lessons Learned and Experience Gained Along the Way. Clin Sports Med 37:495-503
Nguyen, Joseph T; Wasserstein, David; Reinke, Emily K et al. (2017) Does the Chronicity of Anterior Cruciate Ligament Ruptures Influence Patient-Reported Outcomes Before Surgery? Am J Sports Med 45:541-549
Westermann, Robert W; Jones, Morgan; Wasserstein, David et al. (2017) Clinical and radiographic outcomes of meniscus surgery and future targets for biologic intervention: A review of data from the MOON Group. Connect Tissue Res 58:366-372
Lattermann, Christian; Jacobs, Cale A; Reinke, Emily K et al. (2017) Are Bone Bruise Characteristics and Articular Cartilage Pathology Associated with Inferior Outcomes 2 and 6 Years After Anterior Cruciate Ligament Reconstruction? Cartilage 8:139-145
Jones, Morgan H; Spindler, Kurt P (2017) Risk factors for radiographic joint space narrowing and patient reported outcomes of post-traumatic osteoarthritis after ACL reconstruction: Data from the MOON cohort. J Orthop Res 35:1366-1374
Kaeding, Christopher C; Pedroza, Angela D; Reinke, Emily K et al. (2017) Change in Anterior Cruciate Ligament Graft Choice and Outcomes Over Time. Arthroscopy 33:2007-2014
Stegmeier, Nicole; Oak, Sameer R; O'Rourke, Colin et al. (2017) No Clinically Significant Difference Between Adult and Pediatric IKDC Subjective Knee Evaluation Scores in Adults. Sports Health 9:450-455

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