Symptomatic knee osteoarthritis (OA) affects over 14 million people in the US, ~ 70% of whom have meniscal tear. About 400,000 arthroscopic partial meniscectomies (APM) are performed for OA and meniscal tear annually. Although patients live with OA for decades, research on treatment of meniscal tear in patients with OA (physical therapy (PT) or APM) has focused on the first 2 years following treatment. Consequently, there has been little research on the effect of APM or PT on progression of pathologic changes in cartilage, bone, synovium, and other structures. Two especially salient questions remain unanswered about the long-term outcomes in this patient population, and both will be addressed in this proposed 12-year follow-up of subjects in the MeTeOR (Meniscal Tear in OA Research) Trial. First, our preliminary data from MeTeOR, which compared outcomes of APM and PT, suggest APM is associated with more rapid structural progression through 5 years. It is critical to determine whether these effects of APM on OA progression are borne out with longer follow-up, as they are essential for informed discussions about benefits and drawbacks of APM and nonoperative therapy. A more profound research gap is the uncertain clinical interpretation of structural changes on MRI. While clinicians and investigators assume that rapid structural progression of OA results in more severe pain over the long term, there is scant evidence supporting this claim. MeTeOR subjects underwent MRI at baseline, 18-, and 60-months following enrollment, providing a unique opportunity to assess 12-year clinical consequences of structural progression. We propose the following aims: 1. Conduct 12-year follow-up of MeTeOR subjects to characterize the extent of cartilage damage over 12 years and identify factors, including treatment with APM vs. PT, associated with more rapid progression. 2. Assess whether the extent of progression in structural damage over the first 5 years post-treatment in persons with OA and meniscal tear predicts worse symptoms and functional status at 12 years. Successful completion of these Aims will provide clinicians and their patients with crucial data to facilitate informed decisions about treatment for meniscal tear and OA. This work will also test the foundational assumption that structural progression in OA leads, ultimately, to pain and functional limitation.
The MeTeOR Trial compared outcomes of surgery and PT in subjects with painful meniscal tear and osteoarthritis. This study will follow MeTeOR participants out to 12 years of follow-up to address two key questions that affect the health of millions of Americans: whether surgical therapy is associated with faster progression of osteoarthritis, and whether faster progression is associated with worse pain outcomes at 12 years.
|Luc-Harkey, Brittney A; Safran-Norton, Clare E; Mandl, Lisa A et al. (2018) Associations among knee muscle strength, structural damage, and pain and mobility in individuals with osteoarthritis and symptomatic meniscal tear. BMC Musculoskelet Disord 19:258|
|MacFarlane, Lindsey A; Yang, Heidi; Collins, Jamie E et al. (2018) Relationship between patient-reported swelling and MRI-defined effusion-synovitis in patients with meniscus tears and knee osteoarthritis. Arthritis Care Res (Hoboken) :|
|MacFarlane, L A; Yang, H; Collins, J E et al. (2017) Associations among meniscal damage, meniscal symptoms and knee pain severity. Osteoarthritis Cartilage 25:850-857|
|Winter, Amelia R; Collins, Jamie E; Katz, Jeffrey N (2017) The likelihood of total knee arthroplasty following arthroscopic surgery for osteoarthritis: a systematic review. BMC Musculoskelet Disord 18:408|
|Magnussen, Robert A; Reinke, Emily K; Huston, Laura J et al. (2016) Factors Associated With High-Grade Lachman, Pivot Shift, and Anterior Drawer at the Time of Anterior Cruciate Ligament Reconstruction. Arthroscopy 32:1080-5|
|Katz, Jeffrey N; Wright, John; Spindler, Kurt P et al. (2016) Predictors and Outcomes of Crossover to Surgery from Physical Therapy for Meniscal Tear and Osteoarthritis: A Randomized Trial Comparing Physical Therapy and Surgery. J Bone Joint Surg Am 98:1890-1896|
|Tuakli-Wosornu, Yetsa A; Selzer, Faith; Losina, Elena et al. (2016) Predictors of Exercise Adherence in Patients With Meniscal Tear and Osteoarthritis. Arch Phys Med Rehabil 97:1945-1952|
|Losina, Elena; Dervan, Elizabeth E; Paltiel, A David et al. (2015) Defining the Value of Future Research to Identify the Preferred Treatment of Meniscal Tear in the Presence of Knee Osteoarthritis. PLoS One 10:e0130256|
|Katz, Jeffrey N; Brownlee, Sarah A; Jones, Morgan H (2014) The role of arthroscopy in the management of knee osteoarthritis. Best Pract Res Clin Rheumatol 28:143-56|
|Katz, J N; Losina, E (2014) Arthroscopic partial meniscectomy for degenerative tears: where do we stand? Osteoarthritis Cartilage 22:1749-51|
Showing the most recent 10 out of 16 publications