Abstract

It is proposed that we continue our experiments as follows: Finish studies on the ability of the L5178Y S/S variant to complete the restoration of X-ray-induced DNA strand breaks as a function of cycle position following low doses of X-rays (25-500 rads); extend similar investigations to the Chinese hamster ovary cell line and then begin to explore the responses from individual chromosomes of that cell line. Explore further, the response of the L5178Y S/S variant to X-rays as a function of hypo- and hyperthermic pre- and post-irradiation temperatures. Attempt a preliminary identification of the DNA synthetic patterns of the L5178Y S/S variant at defined stages of the cell cycle.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA010714-16
Application #
3163382
Study Section
Radiation Study Section (RAD)
Project Start
1976-02-01
Project End
1987-07-31
Budget Start
1985-08-01
Budget End
1987-07-31
Support Year
16
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Colorado State University-Fort Collins
Department
Type
Schools of Veterinary Medicine
DUNS #
112617480
City
Fort Collins
State
CO
Country
United States
Zip Code
80523

  Publications

Lett, J T; Cox, A B; Story, M D (1989) The role of repair in the survival of mammalian cells from heavy ion irradiation: approximation to the ideal case of target theory. Adv Space Res 9:99-104
Lett, J T; Cox, A B; Story, M D et al. (1989) Responses of synchronous L5178Y S/S cells to heavy ions and their significance for radiobiological theory. Proc R Soc Lond B Biol Sci 237:27-42
Lett, J T; Keng, P C; Bergtold, D S et al. (1987) Effects of heavy ions on rabbit tissues: induction of DNA strand breaks in retinal photoreceptor cells by high doses of radiation. Radiat Environ Biophys 26:23-36
Lett, J T (1987) Cellular radiation biology in consolidation and transition. Br J Cancer Suppl 8:145-52
Lett, J T; Cox, A B; Bergtold, D S (1986) Cellular and tissue responses to heavy ions: basic considerations. Radiat Environ Biophys 25:1-12
Lett, J T; Bertold, D S; Keng, P C (1986) Effects of LET infinity on the fate of DNA damage induced in rabbit sensory cells in situ: fundamental aspects. Basic Life Sci 38:139-50