This is an investigation of the role of (junctional) cell-to-cell communication in cancer growth and the role of communication defects in the etiology of cancerous growth. Sensitive fluorescent tracer techniques were developed for detecting deviations of normal communication. Such deviations were found in various Rous sarcoma-transformed cell types and were shown to be independent of cytoskeletal alterations caused by the virus. A control of communication by hormones (catecholamines and prostaglandins) was found. (A)
| Zimmerman, A L; Rose, B (1985) Permeability properties of cell-to-cell channels: kinetics of fluorescent tracer diffusion through a cell junction. J Membr Biol 84:269-83 |
