Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA014551-20
Application #
2086266
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1978-12-01
Project End
1997-01-31
Budget Start
1995-04-01
Budget End
1997-01-31
Support Year
20
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Boston University
Department
Pathology
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Gallina, Angelo; Hanley, Timothy M; Mandel, Richard et al. (2002) Inhibitors of protein-disulfide isomerase prevent cleavage of disulfide bonds in receptor-bound glycoprotein 120 and prevent HIV-1 entry. J Biol Chem 277:50579-88
Merkel, B J; Mandel, R; Ryser, H J et al. (1995) Characterization of fibroblasts with a unique defect in processing antigens with disulfide bonds. J Immunol 154:128-36
Ryser, H J; Levy, E M; Mandel, R et al. (1994) Inhibition of human immunodeficiency virus infection by agents that interfere with thiol-disulfide interchange upon virus-receptor interaction. Proc Natl Acad Sci U S A 91:4559-63
Mandel, R; Ryser, H J; Ghani, F et al. (1993) Inhibition of a reductive function of the plasma membrane by bacitracin and antibodies against protein disulfide-isomerase. Proc Natl Acad Sci U S A 90:4112-6
Ryser, H J; Mandel, R; Ghani, F (1991) Cell surface sulfhydryls are required for the cytotoxicity of diphtheria toxin but not of ricin in Chinese hamster ovary cells. J Biol Chem 266:18439-42
Mandel, R; Ryser, H J; Niaki, B et al. (1991) Isolation of variants of Chinese hamster ovary cells with abnormally low levels of GSH: decreased ability to cleave endocytosed disulfide bonds. J Cell Physiol 149:60-5
Feener, E P; Shen, W C; Ryser, H J (1990) Cleavage of disulfide bonds in endocytosed macromolecules. A processing not associated with lysosomes or endosomes. J Biol Chem 265:18780-5
Persiani, S; Ballou, B; Shen, W C et al. (1989) In vivo antitumor effect of methotrexate conjugated to a monoclonal IgM antibody specific for stage-specific embryonic antigen-1, on MH-15 mouse teratocarcinoma. Cancer Immunol Immunother 29:167-70
Ryser, H J; Li, W; Mandel, R et al. (1988) Stable variant of LM fibroblast defective in fluid-phase but competent in receptor-mediated endocytosis. J Cell Physiol 137:490-6
Ryser, H J; Mandel, R; Hacobian, A et al. (1988) Methotrexate-poly(lysine) as a selective agent for mutants of Chinese hamster ovary cells defective in endocytosis. J Cell Physiol 135:277-84

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