Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA016312-21
Application #
2086461
Study Section
Experimental Virology Study Section (EVR)
Project Start
1979-05-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Saint Louis University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63103
Mahoney, Kathleen M; Freeman, Gordon J; McDermott, David F (2015) The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma. Clin Ther 37:764-82
Bera, Sibes; Pandey, Krishan K; Vora, Ajaykumar C et al. (2009) Molecular Interactions between HIV-1 integrase and the two viral DNA ends within the synaptic complex that mediates concerted integration. J Mol Biol 389:183-98
Grandgenett, Duane P; Bera, Sibes; Pandey, Krishan K et al. (2009) Biochemical and biophysical analyses of concerted (U5/U3) integration. Methods 47:229-36
Pandey, Krishan K; Grandgenett, Duane P (2008) HIV-1 Integrase Strand Transfer Inhibitors: Novel Insights into their Mechanism of Action. Retrovirology 2:11-16
Zahm, Jacob A; Bera, Sibes; Pandey, Krishan K et al. (2008) Mechanisms of human immunodeficiency virus type 1 concerted integration related to strand transfer inhibition and drug resistance. Antimicrob Agents Chemother 52:3358-68
Pandey, Krishan K; Bera, Sibes; Zahm, Jacob et al. (2007) Inhibition of human immunodeficiency virus type 1 concerted integration by strand transfer inhibitors which recognize a transient structural intermediate. J Virol 81:12189-99
Bera, Sibes; Vora, Ajaykumar C; Chiu, Roger et al. (2005) Synaptic complex formation of two retrovirus DNA attachment sites by integrase: a fluorescence energy transfer study. Biochemistry 44:15106-14
Vora, Ajaykumar; Bera, Sibes; Grandgenett, Duane (2004) Structural organization of avian retrovirus integrase in assembled intasomes mediating full-site integration. J Biol Chem 279:18670-8
Yao, Aqing; Chiu, Roger; Vora, Ajaykumar et al. (2003) Avian retrovirus integrase-enhanced transgene integration into mammalian cell DNA in vivo. Biotechniques 35:1072-6, 1078
Chiu, Roger; Grandgenett, Duane P (2003) Molecular and genetic determinants of rous sarcoma virus integrase for concerted DNA integration. J Virol 77:6482-92

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