Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA016954-11
Application #
3164584
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1981-09-01
Project End
1987-06-30
Budget Start
1987-03-01
Budget End
1987-06-30
Support Year
11
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Type
School of Medicine & Dentistry
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Lin, Hsia-Lien; Zhang, Haoming; Hollenberg, Paul F (2018) Formation of Both Heme and Apoprotein Adducts Contributes to the Mechanism-Based Inactivation of Human CYP2J2 by 17?-Ethynylestradiol. Drug Metab Dispos 46:813-822
Lin, Hsia-Lien; Zhang, Haoming; Walker, Vyvyca J et al. (2017) Heme Modification Contributes to the Mechanism-Based Inactivation of Human Cytochrome P450 2J2 by Two Terminal Acetylenic Compounds. Drug Metab Dispos 45:990-999
Lin, Hsia-Lien; Zhang, Haoming; Kenaan, Cesar et al. (2016) Roles of Residues F206 and V367 in Human CYP2B6: Effects of Mutations on Androgen Hydroxylation, Mechanism-Based Inactivation, and Reversible Inhibition. Drug Metab Dispos 44:1771-1779
Walker, Vyvyca J; Griffin, Alisha P; Hammar, Dagan K et al. (2016) Metabolism of Anandamide by Human Cytochrome P450 2J2 in the Reconstituted System and Human Intestinal Microsomes. J Pharmacol Exp Ther 357:537-44
Snider, Natasha T; Walker, Vyvyca J; Hollenberg, Paul F (2016) Assay of Endocannabinoid Oxidation by Cytochrome P450. Methods Mol Biol 1412:227-36
D'Agostino, Jaime; Zhang, Haoming; Kenaan, Cesar et al. (2015) Mechanism-Based Inactivation of Human Cytochrome P450 2B6 by Chlorpyrifos. Chem Res Toxicol 28:1484-95
Calinski, Diane M; Zhang, Haoming; Ludeman, Susan et al. (2015) Hydroxylation and N-dechloroethylation of Ifosfamide and deuterated Ifosfamide by the human cytochrome p450s and their commonly occurring polymorphisms. Drug Metab Dispos 43:1084-90
Zhang, Haoming; Lauver, D Adam; Lucchesi, Benedict R et al. (2013) Formation, reactivity, and antiplatelet activity of mixed disulfide conjugates of clopidogrel. Mol Pharmacol 83:848-56
Zhang, Haoming; Gay, Sean C; Shah, Manish et al. (2013) Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: implications for allosteric modulation of cytochrome P450 catalysis. Biochemistry 52:355-64
Sridar, Chitra; Hanna, Imad; Hollenberg, Paul F (2013) Quantitation of UGT1A1 in human liver microsomes using stable isotope-labelled peptides and mass spectrometry based proteomic approaches. Xenobiotica 43:336-45

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