Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA017007-15S1
Application #
3164588
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1977-05-01
Project End
1990-12-31
Budget Start
1989-12-01
Budget End
1990-12-31
Support Year
15
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
Organized Research Units
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Roper, Jatin; Tammela, Tuomas; Cetinbas, Naniye Malli et al. (2017) In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nat Biotechnol 35:569-576
Xie, Liang; Duncan, Michael B; Pahler, Jessica et al. (2011) Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner. Proc Natl Acad Sci U S A 108:9939-44
Hynes, Richard O (2009) The extracellular matrix: not just pretty fibrils. Science 326:1216-9
Xu, Lei; Shen, Steven S; Hoshida, Yujin et al. (2008) Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases. Mol Cancer Res 6:760-9
McCarty, Joseph H; Barry, Marc; Crowley, Denise et al. (2008) Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. Am J Pathol 172:1740-7
Wong, Sunny Y; Crowley, Denise; Bronson, Roderick T et al. (2008) Analyses of the role of endogenous SPARC in mouse models of prostate and breast cancer. Clin Exp Metastasis 25:109-18
Wong, Sunny Y; Hynes, Richard O (2007) Tumor-lymphatic interactions in an activated stromal microenvironment. J Cell Biochem 101:840-50
Wong, Sunny Y; Haack, Herbert; Kissil, Joseph L et al. (2007) Protein 4.1B suppresses prostate cancer progression and metastasis. Proc Natl Acad Sci U S A 104:12784-9
Xu, Lei; Hynes, Richard O (2007) GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle 6:160-5
Wong, Sunny Y; Hynes, Richard O (2006) Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide? Cell Cycle 5:812-7

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