Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA017289-21
Application #
2086587
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1979-01-01
Project End
1997-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Salk Institute for Biological Studies
Department
Type
DUNS #
005436803
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Schulte, Roberta J; Sefton, Bartholomew M (2003) Inhibition of the activity of SRC and Abl tyrosine protein kinases by the binding of the Wiskott-Aldrich syndrome protein. Biochemistry 42:9424-30
Kjellen, Peter; Amdjadi, Kambiz; Lund, Troy C et al. (2002) The herpesvirus saimiri tip484 and tip488 proteins both stimulate lck tyrosine protein kinase activity in vivo and in vitro. Virology 297:281-8
Amdjadi, K; Sefton, B M (2000) Ultraviolet light-induced stimulation of the JNK mitogen-activated protein kinase in the absence of src family tyrosine kinase activation. J Biol Chem 275:22520-5
Yurchak, L K; Hardwick, J S; Amrein, K et al. (1996) Stimulation of phosphorylation of Tyr394 by hydrogen peroxide reactivates biologically inactive, non-membrane-bound forms of Lck. J Biol Chem 271:12549-54
Schulte, R J; Campbell, M A; Fischer, W H et al. (1994) Tyrosine phosphorylation of VCP, the mammalian homologue of the Saccharomyces cerevisiae CDC48 protein, is unusually sensitive to stimulation by sodium vanadate and hydrogen peroxide. J Immunol 153:5465-72
Taddie, J A; Hurley, T R; Hardwick, B S et al. (1994) Activation of B- and T-cells by the cytoplasmic domains of the B-cell antigen receptor proteins Ig-alpha and Ig-beta. J Biol Chem 269:13529-35
Taddie, J A; Hurley, T R; Sefton, B M (1994) B-cell activation by wild type and mutant Ig-beta cytoplasmic domains. Adv Exp Med Biol 365:23-34
Schulte, R J; Campbell, M A; Fischer, W H et al. (1992) Tyrosine phosphorylation of CD22 during B cell activation. Science 258:1001-4
Campbell, M A; Sefton, B M (1992) Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases. Mol Cell Biol 12:2315-21
Luo, K; Hurley, T R; Sefton, B M (1990) Transfer of proteins to membranes facilitates both cyanogen bromide cleavage and two-dimensional proteolytic mapping. Oncogene 5:921-3

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