Abstract

1) The structure determination by single crystal X-ray diffraction of new cytotoxic compounds isolated from marine organisms is planned. Emphasis will be given to compounds with high activity and novel structural type. When it is appropriate, the absolute configuration of the compounds will be determined. Also, the structures of several toxic compounds will be determined. It is anticipated that 10-15 compounds will be investigated each year. 2) The synthesis of large quantities of several self-duplexing nucleotides is planned. Crystallization of these nucleotides and complexes with the double intercalator TANDEM will be attempted. The structure of the nucleotides and complexes will be investigated by X-ray diffraction of single crystals and by NMR of solutions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA017562-10
Application #
3164725
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1978-09-01
Project End
1988-07-31
Budget Start
1985-08-01
Budget End
1986-07-31
Support Year
10
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Oklahoma Norman
Department
Type
Schools of Arts and Sciences
DUNS #
848348348
City
Norman
State
OK
Country
United States
Zip Code
73019

  Publications

Schramp, Mark; Ying, Olivia; Kim, Tai Young et al. (2008) ERK5 promotes Src-induced podosome formation by limiting Rho activation. J Cell Biol 181:1195-210
Moghaddam, F M; Amiri, R; Alam, M et al. (1998) Structure and absolute stereochemistry of salvimirzacolide, a new sesterterpene from Salvia mirzayanii. J Nat Prod 61:279-81
Hossain, M B; Van Der Helm, D; Antel, J et al. (1996) Crystal and molecular structure of didemnin A, an antiviral depsipeptide. Int J Pept Protein Res 47:20-7
Fu, X; Ng, P L; Schmitz, F J et al. (1996) Makaluvic acids A and B: novel alkaloids from the marine sponge Zyzzya fuliginosus. J Nat Prod 59:1104-6
Hossain, M B; van der Helm, D; Sangiah, S et al. (1996) 7-Benzyl-3-thia-7-azabicyclo[3.3.1]nonane 3-oxide. Acta Crystallogr C 52 ( Pt 4):995-8
Alam, M; Jones, E B; Hossain, M B et al. (1996) Isolation and structure of isoculmorin from the marine fungus Kallichroma tethys. J Nat Prod 59:454-6
Hossain, M B; van der Helm, D; Schmitz, F J et al. (1994) Molecular structures and conformational studies of triarylcyclopropyl and related nonsteroidal antiestrogens. J Med Chem 37:1670-83
Venkatramani, L; Hossain, M B; Van der Helm, D (1994) Molecular structures of CPF-dipeptides, inhibitors for the binding of CD4 with gp120. Int J Pept Protein Res 43:520-8
Garg, S N; Agarwal, S K; Fidelis, K et al. (1993) New jaeschkeanadiol derivatives from Ferula jaeschkeana. J Nat Prod 56:539-44
Hossain, M B; Symersky, J; Neely, S C et al. (1993) Structure of 1-(4-[2-(diethylamino)ethoxy]phenyl)-2-(4-methoxyphenyl)-1-phenylethan- 1-ol, the non-steroidal antiestrogen MER25. Acta Crystallogr C 49 ( Pt 3):500-4

Showing the most recent 10 out of 20 publications