Abstract

The ultimate aim of these studies is to develop potent antiestrogens capable of controlling growth of estrogen-dependent tumors in humans by non-invasive endocrine therapy. Because of their known specific interaction with estrogen receptors, antiestrogens seem particularly well suited to be specific, antitumor agents in the cases of estrogen-dependent tumors, theoretically capable of achieving non-surgical endocrine therapy. Our studies will assess the interaction of antiestrogens with estrogen receptors in target tissues and their in vivo pharmacokinetic behavior.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA018119-09
Application #
3164849
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1978-12-01
Project End
1985-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
9
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Illinois Urbana-Champaign
Department
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820

  Publications

Aghmesheh, Morteza; Saxena, Akshat; Niknam, Farshid (2015) BRCA1 mutation site may be linked with nuclear DNA ploidy in BRCA1-mutated ovarian carcinomas. Asia Pac J Clin Oncol 11:135-41
Minutolo, Filippo; Macchia, Marco; Katzenellenbogen, Benita S et al. (2011) Estrogen receptor ? ligands: recent advances and biomedical applications. Med Res Rev 31:364-442
Madak-Erdogan, Zeynep; Lupien, Mathieu; Stossi, Fabio et al. (2011) Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs. Mol Cell Biol 31:226-36
Kieser, Karen J; Kim, Dong Wook; Carlson, Kathryn E et al. (2010) Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs). J Med Chem 53:3320-9
Chambliss, Ken L; Wu, Qian; Oltmann, Sarah et al. (2010) Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice. J Clin Invest 120:2319-30
Charn, Tze Howe; Liu, Edison Tak-Bun; Chang, Edmund C et al. (2010) Genome-wide dynamics of chromatin binding of estrogen receptors alpha and beta: mutual restriction and competitive site selection. Mol Endocrinol 24:47-59
Santollo, Jessica; Katzenellenbogen, Benita S; Katzenellenbogen, John A et al. (2010) Activation of ER? is necessary for estradiol's anorexigenic effect in female rats. Horm Behav 58:872-7
Stender, Joshua D; Kim, Kyuri; Charn, Tze Howe et al. (2010) Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation. Mol Cell Biol 30:3943-55
Waibel, Michael; Kieser, Karen J; Carlson, Kathryn E et al. (2009) Phenethyl pyridines with non-polar internal substituents as selective ligands for estrogen receptor beta. Eur J Med Chem 44:3560-70
Hartmaier, R J; Walenkamp, M J E; Richter, A S et al. (2009) A case of premature thelarche with no central cause or genetic variants within the estrogen receptor signaling pathway. J Pediatr Endocrinol Metab 22:751-8

Showing the most recent 10 out of 154 publications