Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA020551-17S1
Application #
3165333
Study Section
Experimental Virology Study Section (EVR)
Project Start
1980-02-01
Project End
1994-06-30
Budget Start
1993-02-10
Budget End
1994-06-30
Support Year
17
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
Rohrschneider, L R; Fuller, J F; Wolf, I et al. (2000) Structure, function, and biology of SHIP proteins. Genes Dev 14:505-20
Bourette, R P; Rohrschneider, L R (2000) Early events in M-CSF receptor signaling. Growth Factors 17:155-66
Lucas, D M; Rohrschneider, L R (1999) A novel spliced form of SH2-containing inositol phosphatase is expressed during myeloid development. Blood 93:1922-33
Bourette, R P; Myles, G M; Choi, J L et al. (1997) Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signaling. EMBO J 16:5880-93
Geier, S J; Algate, P A; Carlberg, K et al. (1997) The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood. Blood 89:1876-85
Rohrschneider, L R; Bourette, R P; Lioubin, M N et al. (1997) Growth and differentiation signals regulated by the M-CSF receptor. Mol Reprod Dev 46:96-103
Carlberg, K; Rohrschneider, L R (1997) Characterization of a novel tyrosine phosphorylated 100-kDa protein that binds to SHP-2 and phosphatidylinositol 3'-kinase in myeloid cells. J Biol Chem 272:15943-50
Lioubin, M N; Algate, P A; Tsai, S et al. (1996) p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity. Genes Dev 10:1084-95
Bourette, R P; Myles, G M; Carlberg, K et al. (1995) Uncoupling of the proliferation and differentiation signals mediated by the murine macrophage colony-stimulating factor receptor expressed in myeloid FDC-P1 cells. Cell Growth Differ 6:631-45
Myles, G M; Brandt, C S; Carlberg, K et al. (1994) Tyrosine 569 in the c-Fms juxtamembrane domain is essential for kinase activity and macrophage colony-stimulating factor-dependent internalization. Mol Cell Biol 14:4843-54

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