Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA020851-24
Application #
6512567
Study Section
Special Emphasis Panel (ZRG1-MEP (05))
Program Officer
Okano, Paul
Project Start
1977-08-01
Project End
2005-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
24
Fiscal Year
2002
Total Cost
$315,793
Indirect Cost

  Institution

Name
New York University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012

  Publications

Zhao, Bo; Wang, Jillian; Geacintov, Nicholas E et al. (2006) Poleta, Polzeta and Rev1 together are required for G to T transversion mutations induced by the (+)- and (-)-trans-anti-BPDE-N2-dG DNA adducts in yeast cells. Nucleic Acids Res 34:417-25
Baskunov, Vladimir B; Subach, Fedor V; Kolbanovskiy, Alexandr et al. (2005) Effects of benzo[a]pyrene-deoxyguanosine lesions on DNA methylation catalyzed by EcoRII DNA methyltransferase and on DNA cleavage effected by EcoRII restriction endonuclease. Biochemistry 44:1054-66
Wu, Min; Yan, S Frank; Tan, Jian et al. (2004) Conformational searches elucidate effects of stereochemistry on structures of deoxyadenosine covalently bound to tumorigenic metabolites of benzo[C] phenanthrene. Front Biosci 9:2807-18
Yan, Shixiang; Wu, Min; Patel, Dinshaw J et al. (2003) Simulating structural and thermodynamic properties of carcinogen-damaged DNA. Biophys J 84:2137-48
Xie, Zhongwen; Braithwaite, Elena; Guo, Dongyu et al. (2003) Mutagenesis of benzo[a]pyrene diol epoxide in yeast: requirement for DNA polymerase zeta and involvement of DNA polymerase eta. Biochemistry 42:11253-62
Huang, Xuanwei; Kolbanovskiy, Alexander; Wu, Xiaohua et al. (2003) Effects of base sequence context on translesion synthesis past a bulky (+)-trans-anti-B[a]P-N2-dG lesion catalyzed by the Y-family polymerase pol kappa. Biochemistry 42:2456-66
Rechkoblit, Olga; Zhang, Yanbin; Guo, Dongyu et al. (2002) trans-Lesion synthesis past bulky benzo[a]pyrene diol epoxide N2-dG and N6-dA lesions catalyzed by DNA bypass polymerases. J Biol Chem 277:30488-94
Huang, Xuanwei; Colgate, Katharine C; Kolbanovskiy, Aleksandr et al. (2002) Conformational changes of a benzo[a]pyrene diol epoxide-N(2)-dG adduct induced by a 5'-flanking 5-methyl-substituted cytosine in a (Me)CG double-stranded oligonucleotide sequence context. Chem Res Toxicol 15:438-44
Zhang, Yanbin; Wu, Xiaohua; Guo, Dongyu et al. (2002) Lesion bypass activities of human DNA polymerase mu. J Biol Chem 277:44582-7
Zhang, Yanbin; Wu, Xiaohua; Guo, Dongyu et al. (2002) Two-step error-prone bypass of the (+)- and (-)-trans-anti-BPDE-N2-dG adducts by human DNA polymerases eta and kappa. Mutat Res 510:23-35

Showing the most recent 10 out of 82 publications