Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA021246-18
Application #
2086935
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1978-02-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Dong, Lijin; Chen, Yong; Lewis, Marcia et al. (2002) Neurologic defects and selective disruption of basement membranes in mice lacking entactin-1/nidogen-1. Lab Invest 82:1617-30
Gresham, H D; Graham, I L; Griffin, G L et al. (1996) Domain-specific interactions between entactin and neutrophil integrins. G2 domain ligation of integrin alpha3beta1 and E domain ligation of the leukocyte response integrin signal for different responses. J Biol Chem 271:30587-94
Durkin, M E; Wewer, U M; Chung, A E (1995) Exon organization of the mouse entactin gene corresponds to the structural domains of the polypeptide and has regional homology to the low-density lipoprotein receptor gene. Genomics 26:219-28
Dong, L J; Hsieh, J C; Chung, A E (1995) Two distinct cell attachment sites in entactin are revealed by amino acid substitutions and deletion of the RGD sequence in the cysteine-rich epidermal growth factor repeat 2. J Biol Chem 270:15838-43
Wu, C; Chung, A E; McDonald, J A (1995) A novel role for alpha 3 beta 1 integrins in extracellular matrix assembly. J Cell Sci 108 ( Pt 6):2511-23
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Donaldson, D J; Mahan, J T; Tsilibary, E C et al. (1994) Migratory interaction of amphibian epidermal cells with components of the basement membrane. J Cell Physiol 158:79-86
Hsieh, J C; Wu, C; Chung, A E (1994) The binding of fibronectin to entactin is mediated through the 29 kDa amino terminal fragment of fibronectin and the G2 domain of entactin. Biochem Biophys Res Commun 199:1509-17
Zagris, N; Stavridis, V; Chung, A E (1993) Appearance and distribution of entactin in the early chick embryo. Differentiation 54:67-71
Yelian, F D; Edgeworth, N A; Dong, L J et al. (1993) Recombinant entactin promotes mouse primary trophoblast cell adhesion and migration through the Arg-Gly-Asp (RGD) recognition sequence. J Cell Biol 121:923-9

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