Abstract

Mammalian cells cultured in vitro will be used to investigate the relative biological effectiveness (RBE) of the low energy emission from Iodine-125 and Cesium-131, at low dose-rates. Our previous investigations involving Iodine-125 at the very low dose-rates characteristic of permanent implants (circa 8 rad/hour) will be extended to the somewhat higher dose-rates likely to be used in removable, temporary implants. The studies will include the newly available radionuclide Cesium-131; dosimetric, microdosimetric and radiobiological measurements will be made. The RBE determinations performed to date with an established line of hamster cells (CHO) will be repeated with normal diploid human fibroblasts which exhibit a survival curve for acute x-ray exposures characterized by a small shoulder. A variety of human cell lines of normal and malignant origin will be used to investigate the relative importance of the repair of sublethal and potentially lethal damage, with reference to the response of the cells to protracted exposures at low dose-rate.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA024232-07
Application #
3166376
Study Section
Radiation Study Section (RAD)
Project Start
1978-09-01
Project End
1986-02-28
Budget Start
1985-03-01
Budget End
1986-02-28
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
Schools of Medicine
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027

  Publications

Brenner, David J; Martinez, Alvaro A; Edmundson, Gregory K et al. (2002) Direct evidence that prostate tumors show high sensitivity to fractionation (low alpha/beta ratio), similar to late-responding normal tissue. Int J Radiat Oncol Biol Phys 52:6-13
Brenner, D J; Little, J B; Sachs, R K (2001) The bystander effect in radiation oncogenesis: II. A quantitative model. Radiat Res 155:402-8
Ponomarev, A L; Cucinotta, F A; Sachs, R K et al. (2001) Monte Carlo predictions of DNA fragment-size distributions for large sizes after HZE particle irradiation. Phys Med 17 Suppl 1:153-6
Brenner, D J; Miller, R C (2001) Long-term efficacy of intracoronary irradiation in inhibiting in-stent restenosis. Circulation 103:1330-2
Ponomarev, A L; Cucinotta, F A; Sachs, R K et al. (2001) Extrapolation of the dna fragment-size distribution after high-dose irradiation to predict effects at low doses. Radiat Res 156:594-7
Brenner, D J; Sachs, R K (2000) Protraction effects in radiation studies: basic biophysics. Radiat Res 154:736-7
Brenner, D J; Hall, E J (1999) Fractionation and protraction for radiotherapy of prostate carcinoma. Int J Radiat Oncol Biol Phys 43:1095-101
Rakovitch, E; Mellado, W; Hall, E J et al. (1999) Penclomedine-induced DNA fragmentation and p53 accumulation correlate with reproductive cell death in colorectal carcinoma cells with altered p53 status. Oncol Rep 6:161-5
Brenner, D J; Leu, C S; Beatty, J F et al. (1999) Clinical relative biological effectiveness of low-energy x-rays emitted by miniature x-ray devices. Phys Med Biol 44:323-33
Brenner, D J (1999) Does fractionation decrease the risk of breast cancer induced by low-LET radiation? Radiat Res 151:225-9

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