Our research covers six different areas related to the cellular evolution characteristic of primary melanomas and to the formal histogenetic precursors of malignant melanoma. These six areas of investigation are: (1) natural language access to the computerized database of all of the melanomas studied prospectively by the Pigmented Lesion Study Group of the University of Pennsylvania; (2) studies of dysplastic nevi, the important histogenetic precursors of melanoma, in familial and sporadic melanoma; (3) fine-structural studies of primary melanomas, dysplastic nevi, normal nevi, and Spitz tumors; (4) studies of the phenotypic characterizations of cells cultured from normal nevi, dysplastic nevi, and melanomas; (5) a variety of studies with antimelanoma monoclonal antibodies emphasizing their use with immunoperoxidase methods to detect melanoma-associated antigens in intact human tumors; and (6) studies of lymphocyte subsets in the host response to melanocytic neoplasms. (W)

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA025298-11
Application #
3166791
Study Section
Pathology B Study Section (PTHB)
Project Start
1978-08-01
Project End
1990-03-31
Budget Start
1989-04-01
Budget End
1990-03-31
Support Year
11
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Clark Jr, W H (1994) From the melanocyte to melanoma to tumor biology. Adv Cancer Res 65:113-40
Lazzaro, B; Elder, D E; Rebers, A et al. (1993) Immunophenotyping of compound and spitz nevi and vertical growth-phase melanomas using a panel of monoclonal antibodies reactive in paraffin sections. J Invest Dermatol 100:313S-317S

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