Abstract

Our research covers six different areas related to the cellular evolution characteristic of primary melanomas and to the formal histogenetic precursors of malignant melanoma. These six areas of investigation are: (1) natural language access to the computerized database of all of the melanomas studied prospectively by the Pigmented Lesion Study Group of the University of Pennsylvania; (2) studies of dysplastic nevi, the important histogenetic precursors of melanoma, in familial and sporadic melanoma; (3) fine-structural studies of primary melanomas, dysplastic nevi, normal nevi, and Spitz tumors; (4) studies of the phenotypic characterizations of cells cultured from normal nevi, dysplastic nevi, and melanomas; (5) a variety of studies with antimelanoma monoclonal antibodies emphasizing their use with immunoperoxidase methods to detect melanoma-associated antigens in intact human tumors; and (6) studies of lymphocyte subsets in the host response to melanocytic neoplasms. (W)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA025298-15
Application #
3166794
Study Section
Pathology B Study Section (PTHB)
Project Start
1978-08-01
Project End
1995-01-31
Budget Start
1993-02-01
Budget End
1994-01-31
Support Year
15
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Seykora, J; Elder, D (1996) Dysplastic nevi and other risk markers for melanoma. Semin Oncol 23:682-7
Elder, D E; Van Belle, P; Elenitsas, R et al. (1996) Neoplastic progression and prognosis in melanoma. Semin Cutan Med Surg 15:336-48
Elder, D E (1995) Skin cancer. Melanoma and other specific nonmelanoma skin cancers. Cancer 75:245-56
Clark Jr, W H (1995) The nature of cancer: morphogenesis and progressive (self)-disorganization in neoplastic development and progression. Acta Oncol 34:3-21
Clark, W H; Goldstein, A M; Tucker, M A (1995) Prospectives for cutaneous malignant melanoma. Considerations of the precursor state and heritability. Br Med Bull 51:717-46
Clark Jr, W H; Tucker, M A; Goldstein, A M (1995) Parenchymal-stromal interactions in neoplasia. Theoretical considerations and observations in melanocytic neoplasia. Acta Oncol 34:749-57
Carey Jr, W P; Thompson, C J; Synnestvedt, M et al. (1994) Dysplastic nevi as a melanoma risk factor in patients with familial melanoma. Cancer 74:3118-25
Isshiki, K; Seng, B A; Elder, D E et al. (1994) Chromosome 9 deletion in sporadic and familial melanomas in vivo. Oncogene 9:1649-53
Clark Jr, W H (1994) From the melanocyte to melanoma to tumor biology. Adv Cancer Res 65:113-40
Lazzaro, B; Elder, D E; Rebers, A et al. (1993) Immunophenotyping of compound and spitz nevi and vertical growth-phase melanomas using a panel of monoclonal antibodies reactive in paraffin sections. J Invest Dermatol 100:313S-317S

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