Abstract

Our main objectives are to continue our studies on carcinogens and chromatin along two broad lines: One dealing with relationships between poly ADP-ribosylation of chromosomal proteins and functions in DNA repair mechanisms; and secondly, to continue our studies on the overall importance of nucleosomal conformation on interactions of carcinogens with DNA.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA025344-10
Application #
3166824
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1979-06-01
Project End
1990-06-30
Budget Start
1988-07-01
Budget End
1989-06-30
Support Year
10
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Georgetown University
Department
Type
School of Medicine & Dentistry
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057

  Publications

Wang, Tao; Simbulan-Rosenthal, Cynthia M; Smulson, Mark E et al. (2008) Polyubiquitylation of PARP-1 through ubiquitin K48 is modulated by activated DNA, NAD+, and dipeptides. J Cell Biochem 104:318-28
Rosenthal, D S; Simbulan-Rosenthal, C M; Liu, W F et al. (2001) Mechanisms of JP-8 jet fuel cell toxicity. II. Induction of necrosis in skin fibroblasts and keratinocytes and modulation of levels of Bcl-2 family members. Toxicol Appl Pharmacol 171:107-16
Stoica, B A; Boulares, A H; Rosenthal, D S et al. (2001) Mechanisms of JP-8 jet fuel toxicity. I. Induction of apoptosis in rat lung epithelial cells. Toxicol Appl Pharmacol 171:94-106
Smulson, M E (1994) Poly(ADP-ribose) polymerase gene on chromosome 1q: early role in differentiation linked replication;gene on human chromosome 13q: marker of carcinogenesis. Mol Cell Biochem 138:77-84
Smulson, M; Istock, N; Ding, R et al. (1994) Deletion mutants of poly(ADP-ribose) polymerase support a model of cyclic association and dissociation of enzyme from DNA ends during DNA repair. Biochemistry 33:6186-91
Stevnsner, T; Ding, R; Smulson, M et al. (1994) Inhibition of gene-specific repair of alkylation damage in cells depleted of poly(ADP-ribose) polymerase. Nucleic Acids Res 22:4620-4
Ding, R; Smulson, M (1994) Depletion of nuclear poly(ADP-ribose) polymerase by antisense RNA expression: influences on genomic stability, chromatin organization, and carcinogen cytotoxicity. Cancer Res 54:4627-34
Blaho, J A; Michael, N; Kang, V et al. (1992) Differences in the poly(ADP-ribosyl)ation patterns of ICP4, the herpes simplex virus major regulatory protein, in infected cells and in isolated nuclei. J Virol 66:6398-407
Ding, R; Pommier, Y; Kang, V H et al. (1992) Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining. J Biol Chem 267:12804-12
Bhatia, K; Kang, V H; Stein, G S et al. (1990) Cell cycle regulation of an exogenous human poly(ADP-ribose) polymerase cDNA introduced into murine cells. J Cell Physiol 144:345-53

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