Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA025583-18
Application #
2087382
Study Section
Experimental Immunology Study Section (EI)
Project Start
1979-04-01
Project End
1999-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Miami School of Medicine
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146
Ilkovitch, Dan; Carrio, Roberto; Lopez, Diana M (2012) uPA and uPA-receptor are involved in cancer-associated myeloid-derived suppressor cell accumulation. Anticancer Res 32:4263-70
Carrio, Roberto; Torroella-Kouri, Marta; Libreros, Stephania et al. (2011) Decreased accumulation of immune regulatory cells is correlated to the antitumor effect of IFN-ýý overexpression in the tumor. Int J Oncol 39:1619-27
Carrio, Roberto; Torroella-Kouri, Marta; Iragavarapu-Charyulu, Vijaya et al. (2011) Tumor-induced thymic atrophy: alteration in interferons and Jak/Stats signaling pathways. Int J Oncol 38:547-53
Carrio, Roberto; Altman, Norman H; Lopez, Diana M (2009) Downregulation of interleukin-7 and hepatocyte growth factor in the thymic microenvironment is associated with thymus involution in tumor-bearing mice. Cancer Immunol Immunother 58:2059-72
Torroella-Kouri, Marta; Silvera, Risset; Rodriguez, Dayron et al. (2009) Identification of a subpopulation of macrophages in mammary tumor-bearing mice that are neither M1 nor M2 and are less differentiated. Cancer Res 69:4800-9
Carrio, Roberto; Lopez, Diana M (2009) Impaired thymopoiesis occurring during the thymic involution of tumor-bearing mice is associated with a down-regulation of the antiapoptotic proteins Bcl-XL and A1. Int J Mol Med 23:89-98
Ilkovitch, Dan; Lopez, Diana M (2009) Urokinase-mediated recruitment of myeloid-derived suppressor cells and their suppressive mechanisms are blocked by MUC1/sec. Blood 113:4729-39
Ilkovitch, Dan; Lopez, Diana M (2009) The liver is a site for tumor-induced myeloid-derived suppressor cell accumulation and immunosuppression. Cancer Res 69:5514-21
Handel-Fernandez, Mary Ellen; Ilkovitch, Dan; Iragavarapu-Charyulu, Vijaya et al. (2009) Decreased levels of both Stat1 and Stat3 in T lymphocytes from mice bearing mammary tumors. Anticancer Res 29:2051-8
Calderon, Cesar L; Torroella-Kouri, Marta; Dinapoli, Michael R et al. (2008) Involvement of protein kinase C and not of NF kappa B in the modulation of macrophage nitric oxide synthase by tumor-derived phosphatidyl serine. Int J Oncol 32:713-21

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