Abstract

The specific aims of this proposal are to evaluate the effectiveness of autologous marrow transplantation (AMT) in patients with acute leukemia and malignant lymphoma. Pretranplant treatment regimens previously tested or being tested in our syngeneic and allogeneic programs will be used with AMT in order to allow comparisons of the relapse rate using the different tupes of marrow. The long-term goal is to ascertain whether or not autologous marrow can be used successfully as an alternative to syngeneic or allogeneic marrow in patients who do not have suitable donors. We will evaluate the effects of posttransplant chemotherapy and the incubation of marrow with monoclonal antibodies in preventing posttransplant relapses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA026828-06
Application #
3167465
Study Section
(SSS)
Project Start
1980-04-01
Project End
1986-05-31
Budget Start
1985-06-01
Budget End
1986-05-31
Support Year
6
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109

  Publications

Hackman, R C; Wolford, J L; Gleaves, C A et al. (1994) Recognition and rapid diagnosis of upper gastrointestinal cytomegalovirus infection in marrow transplant recipients. A comparison of seven virologic methods. Transplantation 57:231-7
Berenson, R J; Bensinger, W I; Hill, R S et al. (1991) Engraftment after infusion of CD34+ marrow cells in patients with breast cancer or neuroblastoma. Blood 77:1717-22
Hill, R S; Mazza, P; Amos, D et al. (1989) Engraftment in 86 with patients lymphoid malignancy after autologous marrow transplantation. Bone Marrow Transplant 4:69-74
Bjornson, B H; Agura, E; Harvey, J M et al. (1988) Endotoxin-associated protein: a potent stimulus for human granulocytopoietic activity which may be accessory cell independent. Infect Immun 56:1602-7
Appelbaum, F R; Nemunaitis, J (1988) Recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) following autologous marrow transplantation in man. Behring Inst Mitt :145-8
Berenson, R J; Andrews, R G; Bensinger, W I et al. (1988) Antigen CD34+ marrow cells engraft lethally irradiated baboons. J Clin Invest 81:951-5
Sanders, J E; Buckner, C D; Amos, D et al. (1988) Ovarian function following marrow transplantation for aplastic anemia or leukemia. J Clin Oncol 6:813-8
Agura, E D; Vila, E; Petersen, F B et al. (1988) The use of ranitidine in bone marrow transplantation. A review of 223 cases. Transplantation 46:53-6
Sanders, J E; Buckner, C D; Sullivan, K M et al. (1988) Growth and development in children after bone marrow transplantation. Horm Res 30:92-7
Nemunaitis, J; Singer, J W; Buckner, C D et al. (1988) Use of recombinant human granulocyte-macrophage colony-stimulating factor in autologous marrow transplantation for lymphoid malignancies. Blood 72:834-6

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