Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA027967-15
Application #
2087670
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1980-04-01
Project End
1997-03-31
Budget Start
1995-07-01
Budget End
1997-03-31
Support Year
15
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Biochemistry
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555
Singh, Sharda P; Janecki, Andrzej J; Srivastava, Sanjay K et al. (2002) Membrane association of glutathione S-transferase mGSTA4-4, an enzyme that metabolizes lipid peroxidation products. J Biol Chem 277:4232-9
Cheng, J Z; Sharma, R; Yang, Y et al. (2001) Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress. J Biol Chem 276:41213-23
Cheng, J Z; Yang, Y; Singh, S P et al. (2001) Two distinct 4-hydroxynonenal metabolizing glutathione S-transferase isozymes are differentially expressed in human tissues. Biochem Biophys Res Commun 282:1268-74
Cheng, J Z; Singhal, S S; Sharma, A et al. (2001) Transfection of mGSTA4 in HL-60 cells protects against 4-hydroxynonenal-induced apoptosis by inhibiting JNK-mediated signaling. Arch Biochem Biophys 392:197-207
Pandya, U; Srivastava, S K; Singhal, S S et al. (2000) Activity of allelic variants of Pi class human glutathione S-transferase toward chlorambucil. Biochem Biophys Res Commun 278:258-62
Awasthi, S; Pandya, U; Singhal, S S et al. (2000) Curcumin-glutathione interactions and the role of human glutathione S-transferase P1-1. Chem Biol Interact 128:19-38
Cheng, J Z; Singhal, S S; Saini, M et al. (1999) Effects of mGST A4 transfection on 4-hydroxynonenal-mediated apoptosis and differentiation of K562 human erythroleukemia cells. Arch Biochem Biophys 372:29-36
Srivastava, S K; Singhal, S S; Hu, X et al. (1999) Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa. Arch Biochem Biophys 366:89-94
Xiao, B; Singh, S P; Nanduri, B et al. (1999) Crystal structure of a murine glutathione S-transferase in complex with a glutathione conjugate of 4-hydroxynon-2-enal in one subunit and glutathione in the other: evidence of signaling across the dimer interface. Biochemistry 38:11887-94
Singhal, S S; Awasthi, S; Pandya, U et al. (1999) The effect of curcumin on glutathione-linked enzymes in K562 human leukemia cells. Toxicol Lett 109:87-95

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