Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA028366-18
Application #
2087720
Study Section
Pathology B Study Section (PTHB)
Project Start
1980-06-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1998-04-30
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wayne State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Santner, S J; Dawson, P J; Tait, L et al. (2001) Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells. Breast Cancer Res Treat 65:101-10
Miller, F R (2000) Xenograft models of premalignant breast disease. J Mammary Gland Biol Neoplasia 5:379-91
Strickland, L B; Dawson, P J; Santner, S J et al. (2000) Progression of premalignant MCF10AT generates heterogeneous malignant variants with characteristic histologic types and immunohistochemical markers. Breast Cancer Res Treat 64:235-40
Wang, B; Miller, F R (2000) Tyrosine phosphorylation of an erbB-2 related p90 protein induced by estrogen in human breast epithelial cells. Int J Oncol 16:1035-42
Miller, F R; Barnbabas, N; Liu, X et al. (1999) Differential display, subtractive hybridization, and application of methodology to search for point mutations to identify genetic defects responsible for progression in MCF10AT model of human breast disease. Electrophoresis 20:256-60
Iravani, S; Mora, L; Miller, F R et al. (1998) Altered expression of c-erbB-2, DF3, b72.3, p53 and Ki-67 with progression and differentiation to two distinct histologic types of invasive carcinoma in the MCF10AT human xenograft model of proliferative breast disease. Int J Oncol 12:369-75
Wang, B; Soule, H D; Miller, F R (1997) Transforming and oncogenic potential of activated c-Ha-ras in three immortalized human breast epithelial cell lines. Anticancer Res 17:4387-94
Wolman, S R; Heppner, G H; Wolman, E (1997) New directions in breast cancer research. FASEB J 11:535-43
Miller, F R (1996) Models of progression spanning preneoplasia and metastasis: the human MCF10AneoT.TGn series and a panel of mouse mammary tumor subpopulations. Cancer Treat Res 83:243-63
Miller, F R; Pauley, R J; Wang, B (1996) Activated c-Ha-ras is not sufficient to produce the preneoplastic phenotype of human breast cell line MCF10AT. Anticancer Res 16:1765-9

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