Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA028735-15
Application #
2087782
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1980-06-01
Project End
1998-06-30
Budget Start
1995-12-01
Budget End
1998-06-30
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Long, Olivia S; Gosai, Sager J; Kwak, Joon Hyeok et al. (2011) Using Caenorhabditis elegans to study serpinopathies. Methods Enzymol 499:259-81
Reizes, Ofer; Goldberger, Olga; Smith, April C et al. (2006) Insulin promotes shedding of syndecan ectodomains from 3T3-L1 adipocytes: a proposed mechanism for stabilization of extracellular lipoprotein lipase. Biochemistry 45:5703-11
Wang, Zihua; Gotte, Martin; Bernfield, Merton et al. (2005) Constitutive and accelerated shedding of murine syndecan-1 is mediated by cleavage of its core protein at a specific juxtamembrane site. Biochemistry 44:12355-61
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Elenius, Varpu; Gotte, Martin; Reizes, Ofer et al. (2004) Inhibition by the soluble syndecan-1 ectodomains delays wound repair in mice overexpressing syndecan-1. J Biol Chem 279:41928-35
Gotte, Martin (2003) Syndecans in inflammation. FASEB J 17:575-91
Gotte, Martin; Joussen, Antonia M; Klein, Christoph et al. (2002) Role of syndecan-1 in leukocyte-endothelial interactions in the ocular vasculature. Invest Ophthalmol Vis Sci 43:1135-41
Park, P W; Pier, G B; Preston, M J et al. (2000) Syndecan-1 shedding is enhanced by LasA, a secreted virulence factor of Pseudomonas aeruginosa. J Biol Chem 275:3057-64
Fitzgerald, M L; Wang, Z; Park, P W et al. (2000) Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase. J Cell Biol 148:811-24
Park, P W; Reizes, O; Bernfield, M (2000) Cell surface heparan sulfate proteoglycans: selective regulators of ligand-receptor encounters. J Biol Chem 275:29923-6

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