Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA029088-14S1
Application #
2550357
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1981-07-15
Project End
1999-05-31
Budget Start
1997-06-01
Budget End
1998-05-31
Support Year
14
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Nebraska Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Omaha
State
NE
Country
United States
Zip Code
68198
Whetstone, Ryan D; Wittel, Uwe A; Michels, Nicole M et al. (2016) Colon carcinogenesis in wild type and immune compromised mice after treatment with azoxymethane, and azoxymethane with dextran sodium sulfate. Mol Carcinog 55:1187-95
Iyer, Prema; Srinivasan, Ajay; Singh, Sreelekha K et al. (2013) Synthesis and characterization of DNA minor groove binding alkylating agents. Chem Res Toxicol 26:156-68
Szulik, Marta W; Voehler, Markus W; Ganguly, Manjori et al. (2013) Site-specific stabilization of DNA by a tethered major groove amine, 7-aminomethyl-7-deaza-2'-deoxyguanosine. Biochemistry 52:7659-68
Srinivasan, Ajay; Wang, Lirong; Cline, Cari J et al. (2012) Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitors. Biochemistry 51:6246-59
Ganguly, Manjori; Szulik, Marta W; Donahue, Patrick S et al. (2012) Thermodynamic signature of DNA damage: characterization of DNA with a 5-hydroxy-2'-deoxycytidine·2'-deoxyguanosine base pair. Biochemistry 51:2018-27
Srinivasan, Ajay; Gold, Barry (2012) Small-molecule inhibitors of DNA damage-repair pathways: an approach to overcome tumor resistance to alkylating anticancer drugs. Future Med Chem 4:1093-111
Singh, Sreelekha K; Szulik, Marta W; Ganguly, Manjori et al. (2011) Characterization of DNA with an 8-oxoguanine modification. Nucleic Acids Res 39:6789-801
Monti, Paola; Broxson, Christopher; Inga, Alberto et al. (2011) 3-Methyl-3-deazaadenine, a stable isostere of N3-methyl-adenine, is efficiently bypassed by replication in vivo and by transcription in vitro. DNA Repair (Amst) 10:861-8
Ganguly, Manjori; Wang, Ruo-Wen; Marky, Luis A et al. (2010) Thermodynamic characterization of DNA with 3-deazaadenine and 3-methyl-3-deazaadenine substitutions: the effect of placing a hydrophobic group in the minor groove of DNA. J Phys Chem B 114:7656-61
Russo, Debora; Fronza, Gilberto; Ottaggio, Laura et al. (2010) XRCC1 deficiency influences the cytotoxicity and the genomic instability induced by Me-lex, a specific inducer of N3-methyladenine. DNA Repair (Amst) 9:728-36

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