Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA029431-16
Application #
2087929
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1981-01-01
Project End
1996-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
Kawano, Takeshi; Ito, Masaki; Raina, Deepak et al. (2007) MUC1 oncoprotein regulates Bcr-Abl stability and pathogenesis in chronic myelogenous leukemia cells. Cancer Res 67:11576-84
Wei, Xiaolong; Xu, Hai; Kufe, Donald (2007) Human mucin 1 oncoprotein represses transcription of the p53 tumor suppressor gene. Cancer Res 67:1853-8
Raina, Deepak; Ahmad, Rehan; Kumar, Shailendra et al. (2006) MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. EMBO J 25:3774-83
Wei, Xiaolong; Xu, Hai; Kufe, Donald (2005) Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. Cancer Cell 7:167-78
Yoshida, Kiyotsugu; Yamaguchi, Tomoko; Natsume, Tohru et al. (2005) JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat Cell Biol 7:278-85
Agata, Naoki; Nogi, Hiroko; Bamberg, Michael et al. (2005) The angiogenesis inhibitor NM-3 is active against human NSCLC xenografts alone and in combination with docetaxel. Cancer Chemother Pharmacol 56:610-4
Raina, Deepak; Pandey, Pramod; Ahmad, Rehan et al. (2005) c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. J Biol Chem 280:11147-51
Huang, Lei; Chen, Dongshu; Liu, Derek et al. (2005) MUC1 oncoprotein blocks glycogen synthase kinase 3beta-mediated phosphorylation and degradation of beta-catenin. Cancer Res 65:10413-22
Raina, Deepak; Kharbanda, Surender; Kufe, Donald (2004) The MUC1 oncoprotein activates the anti-apoptotic phosphoinositide 3-kinase/Akt and Bcl-xL pathways in rat 3Y1 fibroblasts. J Biol Chem 279:20607-12
Li, Quan; Ren, Jian; Kufe, Donald (2004) Interaction of human MUC1 and beta-catenin is regulated by Lck and ZAP-70 in activated Jurkat T cells. Biochem Biophys Res Commun 315:471-6

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