Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA031894-11S1
Application #
3170004
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1989-07-01
Project End
1995-06-30
Budget Start
1992-07-17
Budget End
1993-06-30
Support Year
11
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Rosalind Franklin University
Department
Type
Schools of Medicine
DUNS #
069501252
City
North Chicago
State
IL
Country
United States
Zip Code
60064

  Publications

Datta, P K; Budhiraja, S; Reichel, R R et al. (1997) Regulation of ribosomal RNA gene transcription during retinoic acid-induced differentiation of mouse teratocarcinoma cells. Exp Cell Res 231:198-205
Ghosh, A K; Datta, P K; Jacob, S T (1997) The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo. Oncogene 14:589-94
Ghoshal, K; Jacob, S T (1997) An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug. Biochem Pharmacol 53:1569-75
Ghosh, A K; Niu, H; Jacob, S T (1996) Rat ribosomal RNA gene can utilize primate RNA polymerase I transcription machinery: lack of absolute species specificity in rDNA transcription. Biochem Biophys Res Commun 225:890-5
Ghoshal, K; Jacob, S T (1996) Heat shock inhibits pre-rRNA processing at the primary site in vitro and alters the activity of some rRNA binding proteins. J Cell Biochem 62:506-15
Ghoshal, K; Jacob, S T (1996) Heat shock selectively inhibits ribosomal RNA gene transcription and down-regulates E1BF/Ku in mouse lymphosarcoma cells. Biochem J 317 ( Pt 3):689-95
Niu, H; Zhang, J; Jacob, S T (1995) E1BF/Ku interacts physically and functionally with the core promoter binding factor CPBF and promotes the basal transcription of rat and human ribosomal RNA genes. Gene Expr 4:111-24
Datta, P K; Ghosh, A K; Jacob, S T (1995) The RNA polymerase I promoter-activating factor CPBF is functionally and immunologically related to the basic helix-loop-helix-zipper DNA-binding protein USF. J Biol Chem 270:8637-41
Niu, H; Jacob, S T (1994) Enhancer 1 binding factor (E1BF), a Ku-related protein, is a growth-regulated RNA polymerase I transcription factor: association of a repressor activity with purified E1BF from serum-deprived cells. Proc Natl Acad Sci U S A 91:9101-5
Liu, Z; Jacob, S T (1994) Characterization of a protein that interacts with the rat ribosomal gene promoter and modulates RNA polymerase I transcription. J Biol Chem 269:16618-25

Showing the most recent 10 out of 42 publications