Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA032226-03S1
Application #
3170195
Study Section
Pathology B Study Section (PTHB)
Project Start
1982-05-01
Project End
1985-08-31
Budget Start
1984-05-01
Budget End
1985-08-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost
Name
U.S. Uniformed Services University of Health Science
Department
Type
Schools of Medicine
DUNS #
City
Bethesda
State
MD
Country
United States
Zip Code
20814
Hillmann, A G; Ramdas, J; Multanen, K et al. (2000) Glucocorticoid receptor gene mutations in leukemic cells acquired in vitro and in vivo. Cancer Res 60:2056-62
Ramdas, J; Liu, W; Harmon, J M (1999) Glucocorticoid-induced cell death requires autoinduction of glucocorticoid receptor expression in human leukemic T cells. Cancer Res 59:1378-85
Ramdas, J; Harmon, J M (1998) Glucocorticoid-induced apoptosis and regulation of NF-kappaB activity in human leukemic T cells. Endocrinology 139:3813-21
Sivo, J; Harmon, J M; Vogel, S N (1996) Heat shock mimics glucocorticoid effects on IFN-gamma-induced Fc gamma RI and Ia messenger RNA expression in mouse peritoneal macrophages. J Immunol 156:3450-4
Liu, W; Hillmann, A G; Harmon, J M (1995) Hormone-independent repression of AP-1-inducible collagenase promoter activity by glucocorticoid receptors. Mol Cell Biol 15:1005-13
Denton, R R; Eisen, L P; Elsasser, M S et al. (1993) Differential autoregulation of glucocorticoid receptor expression in human T- and B-cell lines. Endocrinology 133:248-56
Miyashita, Y; Miller, M; Yen, P M et al. (1993) Glucocorticoid receptor binding to rat liver nuclei occurs without nuclear transport. J Steroid Biochem Mol Biol 46:309-20
Powers, J H; Hillmann, A G; Tang, D C et al. (1993) Cloning and expression of mutant glucocorticoid receptors from glucocorticoid-sensitive and -resistant human leukemic cells. Cancer Res 53:4059-65
Scherrer, L C; Picard, D; Massa, E et al. (1993) Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90. Biochemistry 32:5381-6
Palmer, L A; Hukku, B; Harmon, J M (1992) Human glucocorticoid receptor gene deletion following exposure to cancer chemotherapeutic drugs and chemical mutagens. Cancer Res 52:6612-8

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