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Ewald, Brett; Sampath, Deepa; Plunkett, William (2008) ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance. Cancer Res 68:7947-55
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Wang, Yaqing; Liu, Xiaojun; Matsuda, Akira et al. (2008) Repair of 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine-induced DNA single-strand breaks by transcription-coupled nucleotide excision repair. Cancer Res 68:3881-9
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Liu, Xiaojun; Matsuda, Akira; Plunkett, William (2008) Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine. Mol Cancer Ther 7:133-42
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Ewald, B; Sampath, D; Plunkett, W (2008) Nucleoside analogs: molecular mechanisms signaling cell death. Oncogene 27:6522-37
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Ewald, Brett; Sampath, Deepa; Plunkett, William (2007) H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation. Mol Cancer Ther 6:1239-48
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Guo, Lei; Liu, Xiaojun; Nishikawa, Kiyohiro et al. (2007) Inhibition of topoisomerase IIalpha and G2 cell cycle arrest by NK314, a novel benzo[c]phenanthridine currently in clinical trials. Mol Cancer Ther 6:1501-8
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Sampath, Deepa; Cortes, Jorge; Estrov, Zeev et al. (2006) Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial. Blood 107:2517-24
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Sampath, Deepa; Rao, V Ashutosh; Plunkett, William (2003) Mechanisms of apoptosis induction by nucleoside analogs. Oncogene 22:9063-74
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Yang, Li-Ying; Jiang, Hong; Rangel, Kelly M et al. (2003) Cisplatin-induced ubiquitination of RNA polymerase II large subunit and suppression of induction by 7-hydroxystaurosporine (UCN-01). Oncol Rep 10:1489-95
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