Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA032949-10S1
Application #
3170838
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1982-08-01
Project End
1995-05-31
Budget Start
1992-07-22
Budget End
1993-05-31
Support Year
10
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Nebraska Medical Center
Department
Type
Schools of Medicine
DUNS #
City
Omaha
State
NE
Country
United States
Zip Code
68198
Wilken, Jason A; Matsumoto, Kikuko; Laughlin, Lisa S et al. (2002) Comparison of chorionic gonadotropin expression in human and macaque (Macaca fascicularis) trophoblasts. Am J Primatol 56:89-97
Darling, R J; Wilken, J A; Miller-Lindholm, A K et al. (2001) Functional contributions of noncysteine residues within the cystine knots of human chorionic gonadotropin subunits. J Biol Chem 276:10692-9
Darling, R J; Wilken, J A; Ruddon, R W et al. (2001) Intracellular folding pathway of the cystine knot-containing glycoprotein hormone alpha-subunit. Biochemistry 40:577-85
Darling, R J; Ruddon, R W; Perini, F et al. (2000) Cystine knot mutations affect the folding of the glycoprotein hormone alpha-subunit. Differential secretion and assembly of partially folded intermediates. J Biol Chem 275:15413-21
Miller-Lindholm, A K; Bedows, E; Bartels, C F et al. (1999) A naturally occurring genetic variant in the human chorionic gonadotropin-beta gene 5 is assembly inefficient. Endocrinology 140:3496-506
Silva, R A; Sherman, S A; Keiderling, T A (1999) Beta-hairpin stabilization in a 28-residue peptide derived from the beta-subunit sequence of human chorionic gonadotropin hormone. Biopolymers 50:413-23
Muyan, M; Ruddon, R W; Norton, S E et al. (1998) Dissociation of early folding events from assembly of the human lutropin beta-subunit. Mol Endocrinol 12:1640-9
Ruddon, R W; Bedows, E (1997) Assisted protein folding. J Biol Chem 272:3125-8
Miller-Lindholm, A K; LaBenz, C J; Ramey, J et al. (1997) Human chorionic gonadotropin-beta gene expression in first trimester placenta. Endocrinology 138:5459-65
Ruddon, R W; Sherman, S A; Bedows, E (1996) Protein folding in the endoplasmic reticulum: lessons from the human chorionic gonadotropin beta subunit. Protein Sci 5:1443-52

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