Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA034085-14
Application #
2088634
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1983-02-01
Project End
1999-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Pharmacology
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Sadej, Rafal; Inai, Kunihiro; Rajfur, Zenon et al. (2008) Tenascin C interacts with ecto-5'-nucleotidase (eN) and regulates adenosine generation in cancer cells. Biochim Biophys Acta 1782:35-40
Ostapkowicz, Anna; Inai, Kunihiro; Smith, Leia et al. (2006) Lipid rafts remodeling in estrogen receptor-negative breast cancer is reversed by histone deacetylase inhibitor. Mol Cancer Ther 5:238-45
Hunsucker, Sally Anne; Mitchell, Beverly S; Spychala, Jozef (2005) The 5'-nucleotidases as regulators of nucleotide and drug metabolism. Pharmacol Ther 107:1-30
Spychala, Jozef; Kitajewski, Jan (2004) Wnt and beta-catenin signaling target the expression of ecto-5'-nucleotidase and increase extracellular adenosine generation. Exp Cell Res 296:99-108
Spychala, Jozef; Lazarowski, Eduardo; Ostapkowicz, Anna et al. (2004) Role of estrogen receptor in the regulation of ecto-5'-nucleotidase and adenosine in breast cancer. Clin Cancer Res 10:708-17
Mahajan, Kiran N; Mitchell, Beverly S (2003) Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. Proc Natl Acad Sci U S A 100:10746-51
Huang, Min; Wang, Yanhong; Cogut, Susan B et al. (2003) Inhibition of nucleoside transport by protein kinase inhibitors. J Pharmacol Exp Ther 304:753-60
Bianchi, Vera; Spychala, Jozef (2003) Mammalian 5'-nucleotidases. J Biol Chem 278:46195-8
Huang, Min; Wang, Yanhong; Collins, Matthew et al. (2002) A77 1726 induces differentiation of human myeloid leukemia K562 cells by depletion of intracellular CTP pools. Mol Pharmacol 62:463-72
Spychala, Jozef; Mitchell, Beverly S (2002) Cyclosporin A and FK506 decrease adenosine kinase activity and adenosine uptake in T-lymphocytes. J Lab Clin Med 140:84-91

Showing the most recent 10 out of 48 publications