Abstract

Continued effort will be made to generate and characterize monoclonal antibodies specific for later stages of B-cell differentiation. Special emphasis will be made in the identification of plasma cell- and myeloma cell-specific antigens. Human T-T hybridoma technology will continue to be developed and the feasibility of fusion under micromanipulation will be tested. T-cell factors generated by T-T hybridoma and specific for IgM and IgG secretion, as well as factors for Ig isotype switching, will be identified. Emphasis also will be made to identify hidden serum Ig band in CLL patients and to ascertain the feasibility to generate anti-idiotypic monoclonal antibodies to the hidden serum Ig band. T-cell factors which would induce CLL cells to proliferate will be sought. These studies will yield information significant for our understanding of normal and neoplastic B-cell proliferation and differentiation. (LB)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA034546-05
Application #
3172267
Study Section
Experimental Immunology Study Section (EI)
Project Start
1982-07-01
Project End
1988-07-31
Budget Start
1986-08-01
Budget End
1987-07-31
Support Year
5
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Oklahoma Medical Research Foundation
Department
Type
DUNS #
937727907
City
Oklahoma City
State
OK
Country
United States
Zip Code
73104

  Publications

Sung, S; Rose, C E; Fu, S M (2001) Intratracheal priming with ovalbumin- and ovalbumin 323-339 peptide-pulsed dendritic cells induces airway hyperresponsiveness, lung eosinophilia, goblet cell hyperplasia, and inflammation. J Immunol 166:1261-71
Kim, Y; Sung Ss; Kuziel, W A et al. (2001) Enhanced airway Th2 response after allergen challenge in mice deficient in CC chemokine receptor-2 (CCR2). J Immunol 166:5183-92
Kamochi, M; Kamochi, F; Kim, Y B et al. (1999) P-selectin and ICAM-1 mediate endotoxin-induced neutrophil recruitment and injury to the lung and liver. Am J Physiol 277:L310-9
Sung, S J; Taketomi, E A; Smith, A M et al. (1999) Efficient presentation of house dust mite allergen Der p 2 by monocyte-derived dendritic cells and the role of beta 2 integrins. Scand J Immunol 49:96-105
Smith, A M; Yamaguchi, H; Platts-Mills, T A et al. (1998) Prevalence of IgG anti-Der p 2 antibodies in children from high and low antigen exposure groups: relationship of IgG and subclass antibody responses to exposure and allergic symptoms. Clin Immunol Immunopathol 86:102-9
Sung, S S; Guo, C Y; Weed, J M (1997) Monoclonal antibodies against human dendritic cell-like peripheral blood monocytes activated by granulocyte/macrophage-colony-stimulating factor plus interleukin 4. Cell Immunol 182:113-24
Armerding, D; Hren, A; Callard, R E et al. (1996) Induction of cognate and non-cognate T-cell help for B-cell IgE production in relation to CD40 ligand expression. Int Arch Allergy Immunol 111:376-84
Bykowsky, M J; Haire, R N; Ohta, Y et al. (1996) Discordant phenotype in siblings with X-linked agammaglobulinemia. Am J Hum Genet 58:477-83
Gupta, S; Feng, L; Yoshimura, T et al. (1996) Intra-alveolar macrophage-inflammatory peptide 2 induces rapid neutrophil localization in the lung. Am J Respir Cell Mol Biol 15:656-63
Kornfeld, S J; Haire, R N; Strong, S J et al. (1996) A novel mutation (Cys145-->Stop) in Bruton's tyrosine kinase is associated with newly diagnosed X-linked agammaglobulinemia in a 51-year-old male. Mol Med 2:619-23

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