Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA034569-04A1
Application #
3172284
Study Section
Pathology B Study Section (PTHB)
Project Start
1983-05-01
Project End
1987-08-31
Budget Start
1987-01-01
Budget End
1987-08-31
Support Year
4
Fiscal Year
1987
Total Cost
Indirect Cost
Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Overmeyer, Jean H; Kaul, Aparna; Johnson, Erin E et al. (2008) Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis. Mol Cancer Res 6:965-77
Kaul, Aparna; Overmeyer, Jean H; Maltese, William A (2007) Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways. Cell Signal 19:1034-43
Johnson, Erin E; Overmeyer, Jean H; Gunning, William T et al. (2006) Gene silencing reveals a specific function of hVps34 phosphatidylinositol 3-kinase in late versus early endosomes. J Cell Sci 119:1219-32
Ding, Jane; Soule, Gwendolyn; Overmeyer, Jean H et al. (2003) Tyrosine phosphorylation of the Rab24 GTPase in cultured mammalian cells. Biochem Biophys Res Commun 312:670-5
Maltese, William A; Soule, Gwendolyn; Gunning, William et al. (2002) Mutant Rab24 GTPase is targeted to nuclear inclusions. BMC Cell Biol 3:25
Overmeyer, J H; Wilson, A L; Maltese, W A (2001) Membrane targeting of a Rab GTPase that fails to associate with Rab escort protein (REP) or guanine nucleotide dissociation inhibitor (GDI). J Biol Chem 276:20379-86
Erdman, R A; Shellenberger, K E; Overmeyer, J H et al. (2000) Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells. J Biol Chem 275:3848-56
Sheridan, K M; Maltese, W A (1998) Expression of Rab3A GTPase and other synaptic proteins is induced in differentiated NT2N neurons. J Mol Neurosci 10:121-8
Wilson, A L; Erdman, R A; Castellano, F et al. (1998) Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases. Biochem J 333 ( Pt 3):497-504
Overmeyer, J H; Wilson, A L; Erdman, R A et al. (1998) The putative ""switch 2"" domain of the Ras-related GTPase, Rab1B, plays an essential role in the interaction with Rab escort protein. Mol Biol Cell 9:223-35

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