Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA034619-14
Application #
2088724
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1982-09-01
Project End
1997-05-31
Budget Start
1995-06-01
Budget End
1997-05-31
Support Year
14
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Rochester
Department
Pharmacology
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Huang, Rong; Oh, Hyunju; Arrendale, Allison et al. (2013) Intracellular targets for a phosphotyrosine peptidomimetic include the mitotic kinesin, MCAK. Biochem Pharmacol 86:597-611
Marian, Christine; Huang, Rong; Borch, Richard F (2011) Design and synthesis of a potential SH2 domain inhibitor bearing a stereodiversified 1,4-cis-enediol scaffold. Tetrahedron 67:10216-10221
Clark, Michelle K; Scott, Sarah A; Wojtkowiak, Jonathan et al. (2007) Synthesis, biochemical, and cellular evaluation of farnesyl monophosphate prodrugs as farnesyltransferase inhibitors. J Med Chem 50:3274-82
Choi, Jun Young; Borch, Richard F (2007) Highly efficient synthesis of enantiomerically enriched 2-hydroxymethylaziridines by enzymatic desymmetrization. Org Lett 9:215-8
Wu, Weidong; Sigmond, Jennifer; Peters, Godefridus J et al. (2007) Synthesis and biological activity of a gemcitabine phosphoramidate prodrug. J Med Chem 50:3743-6
Boutselis, Irene G; Yu, Xiao; Zhang, Zhong-Yin et al. (2007) Synthesis and cell-based activity of a potent and selective protein tyrosine phosphatase 1B inhibitor prodrug. J Med Chem 50:856-64
Garrido-Hernandez, Hugo; Moon, Kyung D; Geahlen, Robert L et al. (2006) Design and synthesis of phosphotyrosine peptidomimetic prodrugs. J Med Chem 49:3368-76
Wu, Weidong; Borch, Richard F (2006) Synthesis and biological activity of N-2,3-dihydroxypropyl-N-4-chlorobutyl nucleoside phosphoramidate prodrugs. Mol Pharm 3:451-6
Wu, Weidong; Freel Meyers, Caren L; Borch, Richard F (2004) A novel method for the preparation of nucleoside triphosphates from activated nucleoside phosphoramidates. Org Lett 6:2257-60
Tobias, Sandra C; Borch, Richard F (2004) Synthesis and biological evaluation of a cytarabine phosphoramidate prodrug. Mol Pharm 1:112-6

Showing the most recent 10 out of 32 publications