Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA034787-13
Application #
2088773
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1983-06-01
Project End
1996-05-31
Budget Start
1995-06-01
Budget End
1996-05-31
Support Year
13
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Salk Institute for Biological Studies
Department
Type
DUNS #
005436803
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Odorizzi, G; Pearse, A; Domingo, D et al. (1996) Apical and basolateral endosomes of MDCK cells are interconnected and contain a polarized sorting mechanism. J Cell Biol 135:139-52
Buchegger, F; Trowbridge, I S; Liu, L F et al. (1996) Functional analysis of human/chicken transferrin receptor chimeras indicates that the carboxy-terminal region is important for ligand binding. Eur J Biochem 235:9-17
Odorizzi, C G; Trowbridge, I S; Xue, L et al. (1994) Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment. J Cell Biol 126:317-30
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Collawn, J F; Lai, A; Domingo, D et al. (1993) YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis. J Biol Chem 268:21686-92
Trowbridge, I S; Collawn, J F; Hopkins, C R (1993) Signal-dependent membrane protein trafficking in the endocytic pathway. Annu Rev Cell Biol 9:129-61
White, S; Miller, K; Hopkins, C et al. (1992) Monoclonal antibodies against defined epitopes of the human transferrin receptor cytoplasmic tail. Biochim Biophys Acta 1136:28-34
Trowbridge, I S (1991) Endocytosis and signals for internalization. Curr Opin Cell Biol 3:634-41
Collawn, J F; Kuhn, L A; Liu, L F et al. (1991) Transplanted LDL and mannose-6-phosphate receptor internalization signals promote high-efficiency endocytosis of the transferrin receptor. EMBO J 10:3247-53
Trowbridge, I S; Collawn, J; Jing, S et al. (1991) Structure-function analysis of the human transferrin receptor: effects of anti-receptor monoclonal antibodies on tumor growth. Curr Stud Hematol Blood Transfus :139-47

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