Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA035299-10
Application #
3172883
Study Section
Experimental Immunology Study Section (EI)
Project Start
1982-10-01
Project End
1992-03-31
Budget Start
1991-01-10
Budget End
1992-03-31
Support Year
10
Fiscal Year
1990
Total Cost
Indirect Cost
Name
La Jolla Institute
Department
Type
DUNS #
603880287
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Knudson, Karin M; Pritzl, Curtis J; Saxena, Vikas et al. (2017) NF?B-Pim-1-Eomesodermin axis is critical for maintaining CD8 T-cell memory quality. Proc Natl Acad Sci U S A 114:E1659-E1667
Pedros, Christophe; Zhang, Yaoyang; Hu, Joyce K et al. (2016) A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1. Nat Immunol 17:825-33
Wang, Xu-Dong; Gong, Yu; Chen, Zhi-Long et al. (2015) TCR-induced sumoylation of the kinase PKC-? controls T cell synapse organization and T cell activation. Nat Immunol 16:1195-203
Altman, Amnon; Kong, Kok-Fai (2014) Protein kinase C inhibitors for immune disorders. Drug Discov Today 19:1217-21
Kong, Kok-Fai; Fu, Guo; Zhang, Yaoyang et al. (2014) Protein kinase C-? controls CTLA-4-mediated regulatory T cell function. Nat Immunol 15:465-72
Xie, Ji-Ji; Liang, Jia-Qi; Diao, Liang-Hui et al. (2013) TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter. J Immunol 190:4027-36
Zhang, Elizabeth Yan; Kong, Kok-Fai; Altman, Amnon (2013) The yin and yang of protein kinase C-theta (PKC?): a novel drug target for selective immunosuppression. Adv Pharmacol 66:267-312
Kong, Kok-Fai; Altman, Amnon (2013) In and out of the bull's eye: protein kinase Cs in the immunological synapse. Trends Immunol 34:234-42
Altman, Amnon; Kong, Kok-Fai (2012) PKC?: a new target for selective immunosuppression. Expert Rev Clin Immunol 8:205-8
Stahelin, Robert V; Kong, Kok-Fai; Raha, Sumita et al. (2012) Protein kinase C? C2 domain is a phosphotyrosine binding module that plays a key role in its activation. J Biol Chem 287:30518-28

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