Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA035329-10
Application #
2088930
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1984-07-01
Project End
2000-01-31
Budget Start
1996-04-08
Budget End
1997-01-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Roswell Park Cancer Institute Corp
Department
Type
DUNS #
City
Buffalo
State
NY
Country
United States
Zip Code
14263
Xue, Jun; Laine, Roger A; Matta, Khushi L (2015) Enhancing MS(n) mass spectrometry strategy for carbohydrate analysis: A b2 ion spectral library. J Proteomics 112:224-49
Marathe, Dhananjay D; Buffone Jr, Alexander; Chandrasekaran, E V et al. (2010) Fluorinated per-acetylated GalNAc metabolically alters glycan structures on leukocyte PSGL-1 and reduces cell binding to selectins. Blood 115:1303-12
Chandrasekaran, E V; Xue, Jun; Xia, Jie et al. (2008) Reversible sialylation: synthesis of cytidine 5'-monophospho-N-acetylneuraminic acid from cytidine 5'-monophosphate with alpha2,3-sialyl O-glycan-, glycolipid-, and macromolecule-based donors yields diverse sialylated products. Biochemistry 47:320-30
Marathe, Dhananjay D; Chandrasekaran, E V; Lau, Joseph T Y et al. (2008) Systems-level studies of glycosyltransferase gene expression and enzyme activity that are associated with the selectin binding function of human leukocytes. FASEB J 22:4154-67
Chandrasekaran, E V; Xue, Jun; Piskorz, Conrad et al. (2007) Potential tumor markers for human gastric cancer: an elevation of glycan:sulfotransferases and a concomitant loss of alpha1,2-fucosyltransferase activities. J Cancer Res Clin Oncol 133:599-611
Beauharnois, Mark E; Neelamegham, Sriram; Matta, Khushi L (2006) Quantitative measurement of selectin-ligand interactions: assays to identify a sweet pill in a library of carbohydrates. Methods Mol Biol 347:343-58
Xia, Jie; Xue, Jun; Locke, Robert D et al. (2006) Synthesis of fluorinated mucin core 2 branched oligosaccharides with the potential of novel substrates and enzyme inhibitors for glycosyltransferases and sulfotransferases. J Org Chem 71:3696-706
Chandrasekaran, E V; Xue, Jun; Neelamegham, Sriram et al. (2006) The pattern of glycosyl- and sulfotransferase activities in cancer cell lines: a predictor of individual cancer-associated distinct carbohydrate structures for the structural identification of signature glycans. Carbohydr Res 341:983-94
Chandrasekaran, E V; Xue, Jun; Xia, Jie et al. (2005) Analysis of the specificity of sialyltransferases toward mucin core 2, globo, and related structures. identification of the sialylation sequence and the effects of sulfate, fucose, methyl, and fluoro substituents of the carbohydrate chain in the biosynthe Biochemistry 44:15619-35
Beauharnois, Mark E; Lindquist, Kevin C; Marathe, Dhananjay et al. (2005) Affinity and kinetics of sialyl Lewis-X and core-2 based oligosaccharides binding to L- and P-selectin. Biochemistry 44:9507-19

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