Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA036306-12
Application #
2089082
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1984-01-01
Project End
1996-12-31
Budget Start
1995-02-13
Budget End
1996-12-31
Support Year
12
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Heinrich, M C; Hoatlin, M E; Zigler, A J et al. (1998) DNA cross-linker-induced G2/M arrest in group C Fanconi anemia lymphoblasts reflects normal checkpoint function. Blood 91:275-87
Tower, P A; Christianson, T A; Peters, S T et al. (1998) Expression of the Fanconi anemia group C gene in hematopoietic cells is not influenced by oxidative stress, cross-linking agents, radiation, heat, or mitotic inhibitory factors. Exp Hematol 26:19-26
Whitney, M A; Royle, G; Low, M J et al. (1996) Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene. Blood 88:49-58
Heinrich, M C; Dooley, D C; Keeble, W W (1995) Transforming growth factor beta 1 inhibits expression of the gene products for steel factor and its receptor (c-kit). Blood 85:1769-80
Dooley, D C; Oppenlander, B K; Spurgin, P et al. (1995) Basic fibroblast growth factor and epidermal growth factor downmodulate the growth of hematopoietic cells in long-term stromal cultures. J Cell Physiol 165:386-97
Segal, G M; Magenis, R E; Brown, M et al. (1994) Repression of Fanconi anemia gene (FACC) expression inhibits growth of hematopoietic progenitor cells. J Clin Invest 94:846-52
Bagby Jr, G C; Segal, G M; Auerbach, A D et al. (1993) Constitutive and induced expression of hematopoietic growth factor genes by fibroblasts from children with Fanconi anemia. Exp Hematol 21:1419-26
Heinrich, M C; Dooley, D C; Freed, A C et al. (1993) Constitutive expression of steel factor gene by human stromal cells. Blood 82:771-83
Segal, G M; Smith, T D; Heinrich, M C et al. (1992) Specific repression of granulocyte-macrophage and granulocyte colony-stimulating factor gene expression in interleukin-1-stimulated endothelial cells with antisense oligodeoxynucleotides. Blood 80:609-16
Katzen, N A; Segal, G M; Vannier, E et al. (1992) Comparison of granulocyte-macrophage colony stimulating factor and interleukin-1 production from human peripheral blood mononuclear cells as measured by specific radioimmunoassays. Eur Cytokine Netw 3:365-72

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