Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA036481-13
Application #
2089118
Study Section
Pathology B Study Section (PTHB)
Project Start
1984-02-01
Project End
1997-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wayne State University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Calkins, Catharine C; Dosescu, Julie; Day, Nancy A et al. (2007) Functional expression of recombinant human stefin A in mammalian and bacterial cells. Protein Expr Purif 52:463-71
Victor, Bernadette C; Sloane, Bonnie F (2007) Cysteine cathepsin non-inhibitory binding partners: modulating intracellular trafficking and function. Biol Chem 388:1131-40
Reisenauer, Anita; Eickelberg, Oliver; Wille, Aline et al. (2007) Increased carcinogenic potential of myeloid tumor cells induced by aberrant TGF-beta1-signaling and upregulation of cathepsin B. Biol Chem 388:639-50
Sloane, Bonnie F; Sameni, Mansoureh; Podgorski, Izabela et al. (2006) Functional imaging of tumor proteolysis. Annu Rev Pharmacol Toxicol 46:301-15
Song, Jin; Jie, Chunfa; Polk, Paula et al. (2006) The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin. Biochem Biophys Res Commun 340:175-82
Demoz, Marina; Castino, Roberta; Follo, Carlo et al. (2006) High yield synthesis and characterization of phosphorylated recombinant human procathepsin D expressed in mammalian cells. Protein Expr Purif 45:157-67
Jane, Derek T; Morvay, Les; Dasilva, Luis et al. (2006) Cathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pH. Biol Chem 387:223-34
Cavallo-Medved, Dora; Mai, Jianxin; Dosescu, Julie et al. (2005) Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells. J Cell Sci 118:1493-503
Liu, Xu-Wen; Taube, Marcus E; Jung, Ki-Kyung et al. (2005) Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells from extrinsic cell death: a potential oncogenic activity of tissue inhibitor of metalloproteinase-1. Cancer Res 65:898-906
Sloane, Bonnie F; Yan, Shiqing; Podgorski, Izabela et al. (2005) Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment. Semin Cancer Biol 15:149-57

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