Abstract

Seventy-nine marine organisms (51 tunicates, 20 sponges, and 8 molluscs) were collected and evaluated as potential sources of new chemotherapeutic agents. Extracts from 33 organisms exhibited cytotoxicity and 8 inhibited microbes. Isolation and structure studies have been initiated with several of these organisms, Peronia peronii (L1210, IC50 0.5 mug/ml), Eudistoma olivaceum (L1210, IC50 0.33 mug/ml) and Dolabella auricularia (L1210, IC50 0.01 mug/ml). Several active metabolites were isolated and structure studies are in progress. During the three year period of this grant isolation work will be undertaken on the remaining active species from the collection noted above.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA036622-06
Application #
3174220
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1983-09-01
Project End
1993-05-31
Budget Start
1988-08-01
Budget End
1989-05-31
Support Year
6
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Type
Schools of Pharmacy
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Thorson, Megan K; Van Wagoner, Ryan M; Harper, Mary Kay et al. (2015) Marine natural products as inhibitors of cystathionine beta-synthase activity. Bioorg Med Chem Lett 25:1064-6
Sandoval, Imelda T; Manos, Elizabeth J; Van Wagoner, Ryan M et al. (2013) Juxtaposition of chemical and mutation-induced developmental defects in zebrafish reveal a copper-chelating activity for kalihinol F. Chem Biol 20:753-63
Sun, Han; Reinscheid, Uwe M; Whitson, Emily L et al. (2011) Challenge of large-scale motion for residual dipolar coupling based analysis of configuration: the case of fibrosterol sulfate A. J Am Chem Soc 133:14629-36
Dolan, Brian P; Li, Lily; Veltri, Charles A et al. (2011) Distinct pathways generate peptides from defective ribosomal products for CD8+ T cell immunosurveillance. J Immunol 186:2065-72
Lu, Zhenyu; Van Wagoner, Ryan M; Harper, Mary Kay et al. (2011) Mirabamides E-H, HIV-inhibitory depsipeptides from the sponge Stelletta clavosa. J Nat Prod 74:185-93
Pimentel-Elardo, Sheila M; Buback, Verena; Gulder, Tobias A M et al. (2011) New tetromycin derivatives with anti-trypanosomal and protease inhibitory activities. Mar Drugs 9:1682-97
Lu, Zhenyu; Ding, Yuanqing; Li, Xing-Cong et al. (2011) 3-bromohomofascaplysin A, a fascaplysin analogue from a Fijian Didemnum sp. ascidian. Bioorg Med Chem 19:6604-7
Wei, Xiaomei; Henriksen, Niel M; Skalicky, Jack J et al. (2011) Araiosamines A-D: tris-bromoindole cyclic guanidine alkaloids from the marine sponge Clathria (Thalysias) araiosa. J Org Chem 76:5515-23
Lu, Zhenyu; Van Wagoner, Ryan M; Harper, Mary Kay et al. (2010) Two ring-A-aromatized bile acids from the marine sponge Sollasella moretonensis. Nat Prod Commun 5:1571-4
Wei, Xiaomei; Bugni, Tim S; Harper, Mary Kay et al. (2010) Evaluation of pyridoacridine alkaloids in a zebrafish phenotypic assay. Mar Drugs 8:1769-78

Showing the most recent 10 out of 69 publications