Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA036701-11
Application #
2089148
Study Section
Special Emphasis Panel (ZRG3-PTHB (01))
Project Start
1984-01-01
Project End
1999-01-31
Budget Start
1996-04-01
Budget End
1997-01-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Chen, Jin-Qiang; Cammarata, Patrick R; Baines, Christopher P et al. (2009) Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications. Biochim Biophys Acta 1793:1540-70
Yager, James D; Chen, Jin Q (2007) Mitochondrial estrogen receptors--new insights into specific functions. Trends Endocrinol Metab 18:89-91
Yager, James D; Davidson, Nancy E (2006) Estrogen carcinogenesis in breast cancer. N Engl J Med 354:270-82
Chen, Jin-Qiang; Yager, James D; Russo, Jose (2005) Regulation of mitochondrial respiratory chain structure and function by estrogens/estrogen receptors and potential physiological/pathophysiological implications. Biochim Biophys Acta 1746:1-17
Chen, Jin-Qiang; Yager, James D (2004) Estrogen's effects on mitochondrial gene expression: mechanisms and potential contributions to estrogen carcinogenesis. Ann N Y Acad Sci 1028:258-72
Chen, Jin Q; Delannoy, Michael; Cooke, Carol et al. (2004) Mitochondrial localization of ERalpha and ERbeta in human MCF7 cells. Am J Physiol Endocrinol Metab 286:E1011-22
Chen, Jin Q; Eshete, Matthewos; Alworth, William L et al. (2004) Binding of MCF-7 cell mitochondrial proteins and recombinant human estrogen receptors alpha and beta to human mitochondrial DNA estrogen response elements. J Cell Biochem 93:358-73
Chen, Jinqiang; Delannoy, Michael; Odwin, Shelly et al. (2003) Enhanced mitochondrial gene transcript, ATP, bcl-2 protein levels, and altered glutathione distribution in ethinyl estradiol-treated cultured female rat hepatocytes. Toxicol Sci 75:271-8
Li, Yunbo; Seacat, Andrew; Kuppusamy, Periannan et al. (2002) Copper redox-dependent activation of 2-tert-butyl(1,4)hydroquinone: formation of reactive oxygen species and induction of oxidative DNA damage in isolated DNA and cultured rat hepatocytes. Mutat Res 518:123-33
Chen, J; Gokhale, M; Schofield, B et al. (2000) Inhibition of TGF-beta-induced apoptosis by ethinyl estradiol in cultured, precision cut rat liver slices and hepatocytes. Carcinogenesis 21:1205-11

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