Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA037109-09
Application #
2089227
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1983-07-01
Project End
1997-07-14
Budget Start
1996-01-01
Budget End
1997-07-14
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Miami School of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146
Philips, Katherine B; Kurtoglu, Metin; Leung, Howard J et al. (2014) Increased sensitivity to glucose starvation correlates with downregulation of glycogen phosphorylase isoform PYGB in tumor cell lines resistant to 2-deoxy-D-glucose. Cancer Chemother Pharmacol 73:349-61
Xi, Haibin; Kurtoglu, Metin; Lampidis, Theodore J (2014) The wonders of 2-deoxy-D-glucose. IUBMB Life 66:110-21
Sullivan, Elizabeth J; Kurtoglu, Metin; Brenneman, Randall et al. (2014) Targeting cisplatin-resistant human tumor cells with metabolic inhibitors. Cancer Chemother Pharmacol 73:417-27
Xi, Haibin; Barredo, Julio C; Merchan, Jaime R et al. (2013) Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKK? leading to autophagy. Biochem Pharmacol 85:1463-77
Liu, Huaping; Kurtoglu, Metin; Cao, Yenong et al. (2013) Conversion of 2-deoxyglucose-induced growth inhibition to cell death in normoxic tumor cells. Cancer Chemother Pharmacol 72:251-62
Leung, Howard J; Duran, Elda M; Kurtoglu, Metin et al. (2012) Activation of the unfolded protein response by 2-deoxy-D-glucose inhibits Kaposi's sarcoma-associated herpesvirus replication and gene expression. Antimicrob Agents Chemother 56:5794-803
Pina, Y; Decatur, C; Murray, Tg et al. (2011) Advanced retinoblastoma treatment: targeting hypoxia by inhibition of the mammalian target of rapamycin (mTOR) in LH(BETA)T(AG) retinal tumors. Clin Ophthalmol 5:337-43
Xi, Haibin; Kurtoglu, Metin; Liu, Huaping et al. (2011) 2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion. Cancer Chemother Pharmacol 67:899-910
Houston, Samuel K; Pina, Yolanda; Murray, Timothy G et al. (2011) Novel retinoblastoma treatment avoids chemotherapy: the effect of optimally timed combination therapy with angiogenic and glycolytic inhibitors on LH(BETA)T(AG) retinoblastoma tumors. Clin Ophthalmol 5:129-37
Kurtoglu, Metin; Philips, Katherine; Liu, Huaping et al. (2010) High endoplasmic reticulum activity renders multiple myeloma cells hypersensitive to mitochondrial inhibitors. Cancer Chemother Pharmacol 66:129-40

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