Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA037126-12
Application #
2089234
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1984-09-30
Project End
1996-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mcgill University
Department
Type
DUNS #
City
Montreal
State
PQ
Country
Canada
Zip Code
H3 0-G4
Rabbani, S A; Gladu, J; Mazar, A P et al. (1997) Induction in human osteoblastic cells (SaOS2) of the early response genes fos, jun, and myc by the amino terminal fragment (ATF) of urokinase. J Cell Physiol 172:137-45
Goltzman, D (1997) Mechanisms of the development of osteoblastic metastases. Cancer 80:1581-7
Achbarou, A; Kaiser, S; Tremblay, G et al. (1994) Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo. Cancer Res 54:2372-7
Haq, M; Goltzman, D; Tremblay, G et al. (1992) Rat prostate adenocarcinoma cells disseminate to bone and adhere preferentially to bone marrow-derived endothelial cells. Cancer Res 52:4613-9
Goltzman, D; Bolivar, I; Rabbani, S A (1992) Studies on the pathogenesis of osteoblastic metastases by prostate cancer. Adv Exp Med Biol 324:165-71
Rabbani, S A; Mazar, A P; Bernier, S M et al. (1992) Structural requirements for the growth factor activity of the amino-terminal domain of urokinase. J Biol Chem 267:14151-6
Rabbani, S A; Desjardins, J; Bell, A W et al. (1990) An amino-terminal fragment of urokinase isolated from a prostate cancer cell line (PC-3) is mitogenic for osteoblast-like cells. Biochem Biophys Res Commun 173:1058-64
Bidner, S M; Rubins, I M; Desjardins, J V et al. (1990) Evidence for a humoral mechanism for enhanced osteogenesis after head injury. J Bone Joint Surg Am 72:1144-9
Bernier, S M; Desjardins, J; Sullivan, A K et al. (1990) Establishment of an osseous cell line from fetal rat calvaria using an immunocytolytic method of cell selection: characterization of the cell line and of derived clones. J Cell Physiol 145:274-85
Koutsilieris, M; Rabbani, S A; Goltzman, D (1987) Effects of human prostatic mitogens on rat bone cells and fibroblasts. J Endocrinol 115:447-54

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