Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA037372-13
Application #
2089299
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1984-03-15
Project End
1997-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Purdue University
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Fei, Bei; Yu, Shuai; Geahlen, Robert L (2013) Modulation by Syk of Bcl-2, calcium and the calpain-calpastatin proteolytic system in human breast cancer cells. Biochim Biophys Acta 1833:2153-64
Xue, Liang; Geahlen, Robert L; Tao, W Andy (2013) Identification of direct tyrosine kinase substrates based on protein kinase assay-linked phosphoproteomics. Mol Cell Proteomics 12:2969-80
Lipchik, Andrew M; Killins, Renee L; Geahlen, Robert L et al. (2012) A peptide-based biosensor assay to detect intracellular Syk kinase activation and inhibition. Biochemistry 51:7515-24
Arrendale, Allison; Kim, Keunho; Choi, Jun Young et al. (2012) Synthesis of a phosphoserine mimetic prodrug with potent 14-3-3 protein inhibitory activity. Chem Biol 19:764-71
Moon, Kyung D; Zhang, Xiaoying; Zhou, Qing et al. (2012) The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2. Biochim Biophys Acta 1823:199-205
Xue, Liang; Wang, Wen-Horng; Iliuk, Anton et al. (2012) Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates. Proc Natl Acad Sci U S A 109:5615-20
Martin, Victoria A; Wang, Wen-Horng; Lipchik, Andrew M et al. (2012) Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores. Cell Signal 24:1064-73
Galan, Jacob A; Paris, Leela L; Zhang, Hua-jie et al. (2011) Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap. J Am Soc Mass Spectrom 22:319-28
Chen, Chih-Hong; Martin, Victoria A; Gorenstein, Nina M et al. (2011) Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav. Mol Cell Biol 31:2984-96
Paris, Leela L; Hu, Jianjie; Galan, Jacob et al. (2010) Regulation of Syk by phosphorylation on serine in the linker insert. J Biol Chem 285:39844-54

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