Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA037895-11S1
Application #
2727734
Study Section
Experimental Immunology Study Section (EI)
Program Officer
Mahoney, Francis J
Project Start
1985-07-15
Project End
1998-05-31
Budget Start
1997-01-24
Budget End
1998-05-31
Support Year
11
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Center for Molecular Medicine/Immunology
Department
Type
DUNS #
City
Belleville
State
NJ
Country
United States
Zip Code
07950
Karacay, H; Sharkey, R M; McBride, W J et al. (2002) Pretargeting for cancer radioimmunotherapy with bispecific antibodies: role of the bispecific antibody's valency for the tumor target antigen. Bioconjug Chem 13:1054-70
Karacay, H; McBride, W J; Griffiths, G L et al. (2000) Experimental pretargeting studies of cancer with a humanized anti-CEA x murine anti-[In-DTPA] bispecific antibody construct and a (99m)Tc-/(188)Re-labeled peptide. Bioconjug Chem 11:842-54
Losman, M J; Qu, Z; Krishnan, I S et al. (1999) Generation and monitoring of cell lines producing humanized antibodies. Clin Cancer Res 5:3101s-3105s
Karacay, H; Sharkey, R M; Govindan, S V et al. (1997) Development of a streptavidin-anti-carcinoembryonic antigen antibody, radiolabeled biotin pretargeting method for radioimmunotherapy of colorectal cancer. Reagent development. Bioconjug Chem 8:585-94
Sharkey, R M; Karacay, H; Griffiths, G L et al. (1997) Development of a streptavidin-anti-carcinoembryonic antigen antibody, radiolabeled biotin pretargeting method for radioimmunotherapy of colorectal cancer. Studies in a human colon cancer xenograft model. Bioconjug Chem 8:595-604
Sharkey, R M; Blumenthal, R D; Behr, T M et al. (1997) Selection of radioimmunoconjugates for the therapy of well-established or micrometastatic colon carcinoma. Int J Cancer 72:477-85
Riboldi, P; Gaidano, G; Schettino, E W et al. (1995) Cellular origin, antigen reactivity, and VH segment structure of IgM mAbs from AIDS lymphomas. Ann N Y Acad Sci 764:509-18
Blumenthal, R D; Sharkey, R M; Natale, A M et al. (1994) Comparison of equitoxic radioimmunotherapy and chemotherapy in the treatment of human colonic cancer xenografts. Cancer Res 54:142-51
Blumenthal, R D; Sharkey, R M; Haywood, L et al. (1992) Targeted therapy of athymic mice bearing GW-39 human colonic cancer micrometastases with 131I-labeled monoclonal antibodies. Cancer Res 52:6036-44
Sharkey, R M; Boerman, O C; Natale, A et al. (1992) Enhanced clearance of radiolabeled murine monoclonal antibody by a syngeneic anti-idiotype antibody in tumor-bearing nude mice. Int J Cancer 51:266-73

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