Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA038046-12
Application #
2089504
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1984-07-01
Project End
1999-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Johnson, Michael; Morris, Shannon; Chen, Aiping et al. (2004) Selection of functional mutations in the U5-IR stem and loop regions of the Rous sarcoma virus genome. BMC Biol 2:8
Brin, Elena; Leis, Jonathan (2002) HIV-1 integrase interaction with U3 and U5 terminal sequences in vitro defined using substrates with random sequences. J Biol Chem 277:18357-64
Brin, Elena; Leis, Jonathan (2002) Changes in the mechanism of DNA integration in vitro induced by base substitutions in the HIV-1 U5 and U3 terminal sequences. J Biol Chem 277:10938-48
Morris, Shannon; Johnson, Michael; Stavnezer, Ed et al. (2002) Replication of avian sarcoma virus in vivo requires an interaction between the viral RNA and the TpsiC loop of the tRNA(Trp) primer. J Virol 76:7571-7
VerPlank, L; Bouamr, F; LaGrassa, T J et al. (2001) Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55(Gag). Proc Natl Acad Sci U S A 98:7724-9
Xiang, Y; Thorick, R; Vana, M L et al. (2001) Proper processing of avian sarcoma/leukosis virus capsid proteins is required for infectivity. J Virol 75:6016-21
Hindmarsh, P; Johnson, M; Reeves, R et al. (2001) Base-pair substitutions in avian sarcoma virus U5 and U3 long terminal repeat sequences alter the process of DNA integration in vitro. J Virol 75:1132-41
Brin, E; Yi, J; Skalka, A M et al. (2000) Modeling the late steps in HIV-1 retroviral integrase-catalyzed DNA integration. J Biol Chem 275:39287-95
Hindmarsh, P; Ridky, T; Reeves, R et al. (1999) HMG protein family members stimulate human immunodeficiency virus type 1 and avian sarcoma virus concerted DNA integration in vitro. J Virol 73:2994-3003
Morris, S; Leis, J (1999) Changes in Rous sarcoma virus RNA secondary structure near the primer binding site upon tRNATrp primer annealing. J Virol 73:6307-18

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