Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA040615-06S1
Application #
3180857
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1985-08-01
Project End
1993-07-31
Budget Start
1991-01-01
Budget End
1991-07-31
Support Year
6
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Chalasani, Sri Lakshmi; Kawale, Ajinkya S; Akopiants, Konstantin et al. (2018) Persistent 3'-phosphate termini and increased cytotoxicity of radiomimetic DNA double-strand breaks in cells lacking polynucleotide kinase/phosphatase despite presence of an alternative 3'-phosphatase. DNA Repair (Amst) 68:12-24
Menon, Vijay; Povirk, Lawrence F (2016) End-processing nucleases and phosphodiesterases: An elite supporting cast for the non-homologous end joining pathway of DNA double-strand break repair. DNA Repair (Amst) 43:57-68
Alotaibi, Moureq; Sharma, Khushboo; Saleh, Tareq et al. (2016) Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells. Radiat Res 185:229-45
Gewirtz, David A; Alotaibi, Moureq; Yakovlev, Vasily A et al. (2016) Tumor Cell Recovery from Senescence Induced by Radiation with PARP Inhibition. Radiat Res 186:327-332
Almohaini, Mohammed; Chalasani, Sri Lakshmi; Bafail, Duaa et al. (2016) Nonhomologous end joining of complex DNA double-strand breaks with proximal thymine glycol and interplay with base excision repair. DNA Repair (Amst) 41:16-26
Beckta, Jason M; Dever, Seth M; Gnawali, Nisha et al. (2015) Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining. Oncotarget 6:27674-87
Menon, Vijay; Povirk, Lawrence (2014) Involvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ). Subcell Biochem 85:321-36
Akopiants, Konstantin; Mohapatra, Susovan; Menon, Vijay et al. (2014) Tracking the processing of damaged DNA double-strand break ends by ligation-mediated PCR: increased persistence of 3'-phosphoglycolate termini in SCAN1 cells. Nucleic Acids Res 42:3125-37
Mohapatra, Susovan; Yannone, Steven M; Lee, Suk-Hee et al. (2013) Trimming of damaged 3' overhangs of DNA double-strand breaks by the Metnase and Artemis endonucleases. DNA Repair (Amst) 12:422-32
Menon, Vijay R; Peterson, Erica J; Valerie, Kristoffer et al. (2013) Ligand modulation of a dinuclear platinum compound leads to mechanistic differences in cell cycle progression and arrest. Biochem Pharmacol 86:1708-20

Showing the most recent 10 out of 84 publications