Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA040758-10
Application #
2090321
Study Section
Pathology B Study Section (PTHB)
Project Start
1985-08-01
Project End
1997-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10029
Franco, Paola; Vocca, Immacolata; Carriero, Maria V et al. (2006) Activation of urokinase receptor by a novel interaction between the connecting peptide region of urokinase and alpha v beta 5 integrin. J Cell Sci 119:3424-34
Wang, Long G; Ossowski, Liliana; Ferrari, Anna C (2004) Androgen receptor level controlled by a suppressor complex lost in an androgen-independent prostate cancer cell line. Oncogene 23:5175-84
Aguirre-Ghiso, Julio A; Ossowski, Liliana; Rosenbaum, Sarah K (2004) Green fluorescent protein tagging of extracellular signal-regulated kinase and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth. Cancer Res 64:7336-45
Aguirre Ghiso, Julio A (2002) Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo. Oncogene 21:2513-24
Liu, David; Aguirre Ghiso, Julio; Estrada, Yeriel et al. (2002) EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. Cancer Cell 1:445-57
Aguirre-Ghiso, J A; Liu, D; Mignatti, A et al. (2001) Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. Mol Biol Cell 12:863-79
Wang, L G; Ossowski, L; Ferrari, A C (2001) Overexpressed androgen receptor linked to p21WAF1 silencing may be responsible for androgen independence and resistance to apoptosis of a prostate cancer cell line. Cancer Res 61:7544-51
Ossowski, L; Aguirre-Ghiso, J A (2000) Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth. Curr Opin Cell Biol 12:613-20
Gao, M; Ossowski, L; Ferrari, A C (1999) Activation of Rb and decline in androgen receptor protein precede retinoic acid-induced apoptosis in androgen-dependent LNCaP cells and their androgen-independent derivative. J Cell Physiol 179:336-46
Aguirre Ghiso, J A; Kovalski, K; Ossowski, L (1999) Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling. J Cell Biol 147:89-104

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