Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA041233-11
Application #
2090391
Study Section
Pathology B Study Section (PTHB)
Program Officer
Song, Min-Kyung H
Project Start
1992-06-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Sunnybrook & Women's Coll Health Sciences Center
Department
Type
DUNS #
City
Toronto
State
ON
Country
Canada
Zip Code
M4 3-M5
Finer-Moore, Janet S; Lee, Tom T; Stroud, Robert M (2018) A Single Mutation Traps a Half-Sites Reactive Enzyme in Midstream, Explaining Asymmetry in Hydride Transfer. Biochemistry 57:2786-2795
Kerbel, Robert S (2015) A Decade of Experience in Developing Preclinical Models of Advanced- or Early-Stage Spontaneous Metastasis to Study Antiangiogenic Drugs, Metronomic Chemotherapy, and the Tumor Microenvironment. Cancer J 21:274-83
Kuczynski, Elizabeth A; Lee, Christina R; Man, Shan et al. (2015) Effects of Sorafenib Dose on Acquired Reversible Resistance and Toxicity in Hepatocellular Carcinoma. Cancer Res 75:2510-9
Cruz-Muñoz, William; Di Desidero, Teresa; Man, Shan et al. (2014) Analysis of acquired resistance to metronomic oral topotecan chemotherapy plus pazopanib after prolonged preclinical potent responsiveness in advanced ovarian cancer. Angiogenesis 17:661-73
Kerbel, Robert S; Guerin, Eric; Francia, Giulio et al. (2013) Preclinical recapitulation of antiangiogenic drug clinical efficacies using models of early or late stage breast cancer metastatis. Breast 22 Suppl 2:S57-65
Guerin, Eric; Man, Shan; Xu, Ping et al. (2013) A model of postsurgical advanced metastatic breast cancer more accurately replicates the clinical efficacy of antiangiogenic drugs. Cancer Res 73:2743-8
Hackl, Christina; Man, Shan; Francia, Giulio et al. (2013) Metronomic oral topotecan prolongs survival and reduces liver metastasis in improved preclinical orthotopic and adjuvant therapy colon cancer models. Gut 62:259-71
Milsom, Chloe C; Lee, Christina R; Hackl, Christina et al. (2013) Differential post-surgical metastasis and survival in SCID, NOD-SCID and NOD-SCID-IL-2R?(null) mice with parental and subline variants of human breast cancer: implications for host defense mechanisms regulating metastasis. PLoS One 8:e71270
Kuczynski, Elizabeth A; Sargent, Daniel J; Grothey, Axel et al. (2013) Drug rechallenge and treatment beyond progression--implications for drug resistance. Nat Rev Clin Oncol 10:571-87
Cruz-Muñoz, William; Jaramillo, Maria L; Man, Shan et al. (2012) Roles for endothelin receptor B and BCL2A1 in spontaneous CNS metastasis of melanoma. Cancer Res 72:4909-19

Showing the most recent 10 out of 111 publications